Application | Comment | Organism |
---|---|---|
synthesis | developments in 3-hydroxypropionate (HP) production involving the enzyme using Saccharomyces cerevisiae as an industrial host. By combining genome-scale engineering tools, malonyl-CoA biosensors and optimization of downstream fermentation, the production of 3-HP in yeast has the potential to reach or even exceed the yield of chemical production | Chloroflexus aurantiacus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the malonyl-CoA reductase pathway involving the enzyme is successfully constructed in Saccharomyces cerevisiae, developments in 3-hydroxypropionate production using yeast as an industrial host, method, overview. Requirement of improving the supply of the cofactor NADPH due to high expense of NADPH | Chloroflexus aurantiacus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonyl-CoA + NADPH + H+ | Chloroflexus aurantiacus | - |
malonate semialdehyde + CoA + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chloroflexus aurantiacus | Q6QQP7 | bifunctional enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonyl-CoA + NADPH + H+ | - |
Chloroflexus aurantiacus | malonate semialdehyde + CoA + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
malonyl-CoA reductase | UniProt | Chloroflexus aurantiacus |
MCR | - |
Chloroflexus aurantiacus |
More | see also EC 1.1.1.298 | Chloroflexus aurantiacus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Chloroflexus aurantiacus |
General Information | Comment | Organism |
---|---|---|
metabolism | the bifunctional enzyme from Chloroflexus aurantiacus synthesizes 3-hydroxypropionate (3-HP) from malonyl-CoA via the malonyl-CoA reductase pathway, it shows malonyl-CoA reductase activity and converts malonyl-CoA to malonate semialdehyde and CoA using NADPH. The malonate semialdehyde is then reduced to 3-hydroxypropionic acid, EC 1.1.1.298, overview | Chloroflexus aurantiacus |
physiological function | the bifunctional enzyme from Chloroflexus aurantiacus synthesizes 3-hydroxypropionate (3-HP) from malonyl-CoA via the malonyl-CoA reductase pathway, it shows malonyl-CoA reductase activity and converts malonyl-CoA to malonate semialdehyde and CoA using NADPH. The malonate semialdehyde is then reduced to 3-hydroxypropionic acid, EC 1.1.1.298, overview | Chloroflexus aurantiacus |