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Literature summary for 1.2.1.70 extracted from
- Overexpression of HEMA1 encoding glutamyl-tRNA reductase (2011), J. Plant Physiol., 168, 1372-1379.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| AtHemA1 overexpression in Nicotiana tabacum cv Samsun NN using Agrobacterium tumefaciens and Arabidopsis thaliana by transformation | Arabidopsis thaliana |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | as excessive accumulation of GluTR in transgenic plants does not correlate with increased 5-aminolevulinic acid formation, it is hypothesized that 5-aminolevulinic acid synthesis is additionally limited by other effectors that balance the allocation of 5-aminolevulinic acid with the activity of enzymes of chlorophyll and heme biosynthesis | Arabidopsis thaliana |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | formation of 5-aminolevulinic acid in 5-week-old AtHEMA1-expressing tobacco plants grown in continuous light could be shown to be significantly altered but does not result in significant changes of the amounts of tetrapyrrole intermediates, chlorophyll or heme | Arabidopsis thaliana | ? | - |
? |  |
| additional information | up to 7fold increased GluTR content in adult transgenic Arabidopsis plants two days after ethanol application but there is no significant increase in 5-aminolevulinic acid synthesis rates in comparison to ethanol-treated wild-type plants | Arabidopsis thaliana | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AtHEMA1 | - |
Arabidopsis thaliana |
| glutamyl-tRNA reductase | - |
Arabidopsis thaliana |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | GluTR is the first committed enzyme of plant 5-aminolevulinic acid synthesis and 5-aminolevulinic acid synthesis has been shown to be the rate limiting step of tetrapyrrole biosynthesis | Arabidopsis thaliana |
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Release 2023.1 (January 2023)
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