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Literature summary for 1.2.1.60 extracted from

  • Fawcett, T.; Garrido-Pertierra, A.; Cooper, R.A.
    5-Carboxymethyl-2-hydroxymuconic semialdehyde dehydrogenases of Escherichia coli C and Klebsiella pneumoniae M5a1 show very high N-terminal sequence homology (1989), FEMS Microbiol. Lett., 57, 307-312.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
5-carboxymethyl-2-hydroxymuconate semialdehyde
-
Klebsiella pneumoniae
0.009
-
5-carboxymethyl-2-hydroxymuconate semialdehyde
-
Escherichia coli
0.012
-
NAD+
-
Klebsiella pneumoniae
0.02
-
NAD+
-
Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
2 * 52000, SDS-PAGE Escherichia coli
52000
-
2 * 52000, SDS-PAGE Klebsiella pneumoniae
102000
-
gel filtration Klebsiella pneumoniae
125000
-
gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ Escherichia coli
-
5-carboxymethyl-2-hydroxymuconate + NADH
-
?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ Klebsiella pneumoniae
-
5-carboxymethyl-2-hydroxymuconate + NADH
-
?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ Klebsiella pneumoniae M5a1
-
5-carboxymethyl-2-hydroxymuconate + NADH
-
?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ Escherichia coli C
-
5-carboxymethyl-2-hydroxymuconate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli C
-
-
-
Klebsiella pneumoniae
-
-
-
Klebsiella pneumoniae M5a1
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, chromatography techniques Escherichia coli
to homogeneity, chromatography techniques Klebsiella pneumoniae

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Escherichia coli
-
cell culture
-
Klebsiella pneumoniae
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
35
-
-
Escherichia coli
54
-
-
Escherichia coli
54
-
-
Klebsiella pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
-
Escherichia coli 5-carboxymethyl-2-hydroxymuconate + NADH
-
?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
-
Klebsiella pneumoniae 5-carboxymethyl-2-hydroxymuconate + NADH
-
?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
-
Klebsiella pneumoniae M5a1 5-carboxymethyl-2-hydroxymuconate + NADH
-
?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
-
Escherichia coli C 5-carboxymethyl-2-hydroxymuconate + NADH
-
?

Subunits

Subunits Comment Organism
dimer 2 * 52000, SDS-PAGE Escherichia coli
dimer 2 * 52000, SDS-PAGE Klebsiella pneumoniae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Escherichia coli
7.5
-
-
Klebsiella pneumoniae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Escherichia coli
NAD+
-
Klebsiella pneumoniae