Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.48 extracted from

  • Kitamura, T.; Takagi, S.; Naganuma, T.; Kihara, A.
    Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification (2015), Biochem. J., 465, 79-87 .
    View publication on PubMed
Search for more literature for 1.2.1.48

Localization

Localization Comment Organism GeneOntology No. Textmining
lipid droplet
-
 Mus musculus 5811
-
additional information the C-terminal regions, particularly the two tryptophan residues (Trp462 and Trp469) of isozyme ALDH3B2 and the two arginine residues (Arg462 and Arg463) of isozyme ALDH3B3, are important for the determination of their specific localization Mus musculus
-
-
plasma membrane
-
 Mus musculus 5886
-

Organism

Organism UniProt Comment Textmining
Mus musculus E9Q3E1
-
-
Mus musculus J3QMK6
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
lipoprotein enzyme ALDH3B2 is modified by prenylation at its C-terminus. The modification greatly influences its membrane localization and enzymatic activity towards hexadecanal Mus musculus
lipoprotein enzyme ALDH3B3 is modified by prenylation at its C-terminus. The modification greatly influences its membrane localization and enzymatic activity towards hexadecanal Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hexadecanal + NAD+ + H2O
-
 Mus musculus hexadecanoate + NADH + 2 H+
-
 ?
additional information the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes Mus musculus ?
-
 ?
additional information the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
ALDH3B2
-
 Mus musculus
ALDH3B3
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mus musculus

General Information

General Information Comment Organism
evolution the enzyme is a member of the ALDH3 family Mus musculus
physiological function ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2 and ALDH3B3) are responsible for the removal of lipid-derived aldehydes Mus musculus
physiological function ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2 and ALDH3B3) are responsible for the removal of lipid-derived aldehydes. Isozyme ALDH3B2 probably acts to remove lipid-derived aldehydes in lipid droplets generated via oxidative stress as a quality control mechanism Mus musculus