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Literature summary for 1.2.1.48 extracted from
- Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal (2010), J. Lipid Res., 51, 1554-1559.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
2 * 55000, SDS-PAGE | Mus musculus |
| 55000 | - |
2 * 55000, SDS-PAGE | Homo sapiens |
| 55000 | - |
2 * 55000, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cis,cis-9,12-octadecadienal + NAD+ + H2O | Mus musculus | major substrate | cis,cis-9,12-octadecadienoic acid + NADH | - |
? |  |
| cis,cis-9,12-octadecadienal + NAD+ + H2O | Homo sapiens | major substrate | cis,cis-9,12-octadecadienoic acid + NADH | - |
? | |
| cis,cis-9,12-octadecadienal + NAD+ + H2O | Rattus norvegicus | major substrate | cis,cis-9,12-octadecadienoic acid + NADH | - |
? | |
| long-chain aldehyde + NAD+ + H2O | Mus musculus | - |
long-chain acid anion + NADH | - |
? | |
| long-chain aldehyde + NAD+ + H2O | Homo sapiens | - |
long-chain carboxylate + NADH | - |
? | |
| long-chain aldehyde + NAD+ + H2O | Rattus norvegicus | - |
long-chain carboxylate + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Strep-tag affinity chromatography and AMP-Sepharose column chromatography | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Mus musculus | - |
| cerebellum | - |
Mus musculus | - |
| cerebrum | - |
Mus musculus | - |
| fibroblast | - |
Homo sapiens | - |
| heart | low activity | Mus musculus | - |
| kidney | - |
Mus musculus | - |
| large intestine | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Mus musculus | - |
| ovary | high activity | Mus musculus | - |
| skeletal muscle | low activity | Mus musculus | - |
| spleen | - |
Mus musculus | - |
| stomach | - |
Mus musculus | - |
| stomach | high activity | Mus musculus | - |
| subcutaneous adipose tissue | - |
Mus musculus | - |
| testis | high activity | Mus musculus | - |
| visceral fat | high activity | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cis,cis-9,12-octadecadienal + NAD+ + H2O | major substrate | Mus musculus | cis,cis-9,12-octadecadienoic acid + NADH | - |
? | |
| cis,cis-9,12-octadecadienal + NAD+ + H2O | major substrate | Homo sapiens | cis,cis-9,12-octadecadienoic acid + NADH | - |
? | |
| cis,cis-9,12-octadecadienal + NAD+ + H2O | major substrate | Rattus norvegicus | cis,cis-9,12-octadecadienoic acid + NADH | - |
? | |
| long-chain aldehyde + NAD+ + H2O | - |
Mus musculus | long-chain acid anion + NADH | - |
? | |
| long-chain aldehyde + NAD+ + H2O | - |
Homo sapiens | long-chain carboxylate + NADH | - |
? | |
| long-chain aldehyde + NAD+ + H2O | - |
Rattus norvegicus | long-chain carboxylate + NADH | - |
? | |
| pyrenedecanal + NAD+ + H2O | - |
Mus musculus | pyrenedecanoic acid + NADH | - |
? | |
| pyrenedecanal + NAD+ + H2O | - |
Homo sapiens | pyrenedecanoic acid + NADH | - |
? | |
| pyrenedecanal + NAD+ + H2O | - |
Rattus norvegicus | pyrenedecanoic acid + NADH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 55000, SDS-PAGE | Mus musculus |
| homodimer | 2 * 55000, SDS-PAGE | Homo sapiens |
| homodimer | 2 * 55000, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ALDH3A2 | - |
Mus musculus |
| ALDH3A2 | - |
Homo sapiens |
| ALDH3A2 | - |
Rattus norvegicus |
| fatty aldehyde dehydrogenase | - |
Mus musculus |
| fatty aldehyde dehydrogenase | - |
Homo sapiens |
| fatty aldehyde dehydrogenase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Mus musculus | |
| NAD+ | - |
Homo sapiens | |
| NAD+ | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | deficiency in fatty aldehyde dehydrogenase causes the Sjogren Larsson Syndrome, a rare inherited disorder characterized by ichthyosis, spasticity, and mental retardation | Homo sapiens |
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Release 2023.1 (January 2023)
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