Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.47 extracted from

  • Garcia-Delgado, M.; Peral, M.J.; Duran, J.M.; Garcia-Miranda, P.; Calonge, M.L.; Ilundain, A.A.
    Ontogeny of Na(+)/L-carnitine transporter and of gamma-trimethylaminobutyraldehyde dehydrogenase and gamma-butyrobetaine hydroxylase genes expression in rat kidney (2009), Mech. Ageing Dev., 130, 227-233.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trimethylaminobutyraldehyde + NAD+ + H2O Rattus norvegicus enzyme is involved in L-carnitine (3-hydroxy-4-N-trimethylaminobutyrate) biosynthesis gamma-butyrobetaine + NADH + 2 H+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q9JLJ3 foetuses, newborn, suckling, weaning and adult rats
-
Rattus norvegicus Q9JLJ3 male Wister rat
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
renal cortex
-
Rattus norvegicus
-
renal medulla
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
expression of TMABA-DH is ontogenically regulated, renal levels of TMABA-DH are quantified by real-time PCR assays in foetuses, newborn, suckling, weaning and 2-month-old rats, foetuses express TMABA-DH mRNA and this expression increases significantly with maturation, comparisons between cortex and medulla reveals that, except for foetuses and newborn rats, TMABA-DHmRNA levels are significantly higher in the medulla than in the cortex Rattus norvegicus
additional information
-
levels of liver mRNA TMABA-DH are approximately 2times greater than the maximal values measured in kidneys Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trimethylaminobutyraldehyde + NAD+ + H2O enzyme is involved in L-carnitine (3-hydroxy-4-N-trimethylaminobutyrate) biosynthesis Rattus norvegicus gamma-butyrobetaine + NADH + 2 H+
-
?

Synonyms

Synonyms Comment Organism
4-trimethylammoniobutyraldehyde dehydrogenase
-
Rattus norvegicus
gamma-trimethylaminobutyraldehyde dehydrogenase
-
Rattus norvegicus
TMABA-DH
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus detection of mRNA levels in foetuses, increase during postnatal life, expression is ontogenically regulated up