Literature summary for 1.2.1.4 extracted from

Lee, S.; Park, D.J.; Yoon, J.; Bang, S.H.; Kim, Y.H.; Min, J.
Formaldehyde treatment using overexpressed aldehyde dehydrogenase 6 from recombinant Saccharomyces cerevisiae (2018), J. Nanosci. Nanotechnol., 18, 2979-2985 .

Search for more literature for 1.2.1.4

Cloned(Commentary)

Cloned (Comment)	Organism
gene ALD6, recombinant overexpression of wild-type and mutant GFP-tagged enzymes in Saccharomyces cerevisiae strain MBTL-SYL-1 cytosol	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of an enzyme mutant with deletion of the catalytic residues	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Saccharomyces cerevisiae	5829	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	the enzyme is activated by Mg2+	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetaldehyde + NADP+	Saccharomyces cerevisiae	-	acetate + NADPH + H+	-	?
formaldehyde + NADP+	Saccharomyces cerevisiae	-	formate + NADPH + H+	-	?
formaldehyde + NADP+	Saccharomyces cerevisiae ATCC 204508	-	formate + NADPH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P54115	-	-
Saccharomyces cerevisiae ATCC 204508	P54115	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetaldehyde + NAD+	-	Saccharomyces cerevisiae	acetate + NADH + H+	-	?
acetaldehyde + NADP+	-	Saccharomyces cerevisiae	acetate + NADPH + H+	-	?
formaldehyde + NAD+	-	Saccharomyces cerevisiae	formate + NADH + H+	-	?
formaldehyde + NAD+	-	Saccharomyces cerevisiae ATCC 204508	formate + NADH + H+	-	?
formaldehyde + NADP+	-	Saccharomyces cerevisiae	formate + NADPH + H+	-	?
formaldehyde + NADP+	-	Saccharomyces cerevisiae ATCC 204508	formate + NADPH + H+	-	?
additional information	NADH/formaldehyde detection by luminescence assay using Vibrio fischeri	Saccharomyces cerevisiae	?	-	-
additional information	NADH/formaldehyde detection by luminescence assay using Vibrio fischeri	Saccharomyces cerevisiae ATCC 204508	?	-	-

Synonyms

Synonyms	Comment	Organism
aldehyde dehydrogenase 6	-	Saccharomyces cerevisiae
ALDH1F1	-	Saccharomyces cerevisiae
ALDH6	-	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Saccharomyces cerevisiae
NADP+	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)