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Literature summary for 1.2.1.4 extracted from
- Kinetics of membrane-bound aldehyde dehydrogenase from Acinetobacter calcoaceticus (1987), Biol. Chem. Hoppe-Seyler, 368, 101-109.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| butyric acid ethyl ester | - |
Acinetobacter calcoaceticus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | non-competitive | Acinetobacter calcoaceticus | |
| BO33- | non-competitive | Acinetobacter calcoaceticus | |
| Butanal | substrate inhibition | Acinetobacter calcoaceticus | |
| Chloralhydrate | non-competitive | Acinetobacter calcoaceticus | |
| CN- | non-competitive | Acinetobacter calcoaceticus | |
| Cu2+ | non-competitive | Acinetobacter calcoaceticus | |
| decanal | substrate inhibition | Acinetobacter calcoaceticus | |
| diisopropylfluorophosphate | non-competitive | Acinetobacter calcoaceticus | |
| EDTA | non-competitive | Acinetobacter calcoaceticus | |
| Fe2+ | non-competitive | Acinetobacter calcoaceticus | |
| hexanal | substrate inhibition | Acinetobacter calcoaceticus | |
| mercaptoethanol | non-competitive | Acinetobacter calcoaceticus | |
| NADPH | product inhibition | Acinetobacter calcoaceticus | |
| octanal | substrate inhibition | Acinetobacter calcoaceticus | |
| PCMB | non-competitive | Acinetobacter calcoaceticus | |
| Phenylmethylsulfonylfluoride | non-competitive | Acinetobacter calcoaceticus | |
| Sn2+ | non-competitive | Acinetobacter calcoaceticus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0015 | - |
decanal | - |
Acinetobacter calcoaceticus | |
| 0.0039 | - |
Nonanal | - |
Acinetobacter calcoaceticus | |
| 0.0093 | - |
octanal | - |
Acinetobacter calcoaceticus | |
| 0.055 | - |
Heptanal | - |
Acinetobacter calcoaceticus | |
| 0.056 | - |
NADP+ | reaction with heptanal | Acinetobacter calcoaceticus | |
| 0.064 | - |
NADP+ | reaction with nonanal | Acinetobacter calcoaceticus | |
| 0.077 | - |
NADP+ | reaction with pentanal | Acinetobacter calcoaceticus | |
| 0.087 | - |
NADP+ | reaction with octanal | Acinetobacter calcoaceticus | |
| 0.1 | - |
NADP+ | reaction with decanal | Acinetobacter calcoaceticus | |
| 0.14 | - |
NADP+ | reaction with butanal | Acinetobacter calcoaceticus | |
| 0.21 | - |
NADP+ | reaction with hexanal | Acinetobacter calcoaceticus | |
| 0.46 | - |
hexanal | - |
Acinetobacter calcoaceticus | |
| 0.92 | - |
pentanal | - |
Acinetobacter calcoaceticus | |
| 1.6 | - |
Butanal | - |
Acinetobacter calcoaceticus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Acinetobacter calcoaceticus | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Acinetobacter calcoaceticus | inducible enzyme | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acinetobacter calcoaceticus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butanal + NADP+ + H2O | - |
Acinetobacter calcoaceticus | butyrate + NADPH + H+ | - |
? | |
| decanal + NADP+ | - |
Acinetobacter calcoaceticus | decanoate + NADPH | - |
? | |
| heptanal + NADP+ | - |
Acinetobacter calcoaceticus | heptanoate + NADPH | - |
? | |
| hexanal + NADP+ | - |
Acinetobacter calcoaceticus | hexanoate + NADPH | - |
? | |
| additional information | inducible enzyme | Acinetobacter calcoaceticus | ? | - |
? | |
| nonanal + NAD+ + H2O | - |
Acinetobacter calcoaceticus | nonanoate + NADH + H+ | - |
r | |
| octanal + NADP+ + H2O | - |
Acinetobacter calcoaceticus | octanoate + NADPH + H+ | - |
? | |
| pentanal + NADP+ | - |
Acinetobacter calcoaceticus | pentanoate + NADPH | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | 10.5 | - |
Acinetobacter calcoaceticus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 11.5 | pH 8.5: about 60% of maximal activity, pH 11.5: about 80% of maximal activity | Acinetobacter calcoaceticus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | reaction with NAD+ is less than 1% of the activity with NADP+ | Acinetobacter calcoaceticus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000000014 | - |
PCMB | - |
Acinetobacter calcoaceticus | |
| 0.0055 | - |
1,10-phenanthroline | - |
Acinetobacter calcoaceticus | |
| 0.0095 | - |
Chloralhydrate | - |
Acinetobacter calcoaceticus | |
| 0.027 | - |
EDTA | - |
Acinetobacter calcoaceticus | |
| 0.035 | - |
decanal | - |
Acinetobacter calcoaceticus | |
| 0.1 | - |
octanal | - |
Acinetobacter calcoaceticus | |
| 0.22 | - |
NADPH | - |
Acinetobacter calcoaceticus | |
| 1 | - |
hexanal | - |
Acinetobacter calcoaceticus | |
| 7.5 | - |
Butanal | - |
Acinetobacter calcoaceticus | |
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