Literature summary for 1.2.1.36 extracted from

Bui, T.B.C.; Nosaki, S.; Kokawa, M.; Xu, Y.; Kitamura, Y.; Tanokura, M.; Hachimura, S.; Miyakawa, T.
Evaluation of spice and herb as phyto-derived selective modulators of human retinaldehyde dehydrogenases using a simple in vitro method (2021), Biosci. Rep., 41, BSR20210491 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli Rosetta(DE3) cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
4-(1,3-dihydro-2H-isoindol-2-yl)benzaldehyde	-	Homo sapiens
4-dimethylamino-4-methyl-pent-2-ynthioic acid S-methyl ester	-	Homo sapiens
dimethyl ampal thiolester	-	Homo sapiens
Mg2+	at 30 mM Mg2+, significant inhibition of activity is shown for isoform RALDH1; at 30 mM Mg2+, significant inhibition of activity is shown for isoform RALDH2	Homo sapiens
additional information	not inhibited by trans-anethole; not inhibited by trans-anethole; not inhibited by trans-anethole	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	the presence of 1 mM magnesium ions significantly increases the activity for the natural substrate retinal of isoform RALDH3	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
all-trans retinal + NAD+ + H2O	Homo sapiens	-	all-trans retinoate + NADH + 2 H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O94788	-	-
Homo sapiens	P00352	-	-
Homo sapiens	P47895	-	-

Purification (Commentary)

Purification (Comment)	Organism
nickel chelating resin column chromatography and Superdex 200 gel filtration	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
all-trans retinal + NAD+ + H2O	-	Homo sapiens	all-trans retinoate + NADH + 2 H+	-	?

Subunits

Subunits	Comment	Organism
?	x * about 50000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ALDH1A1	-	Homo sapiens
Aldh1a2	-	Homo sapiens
Aldh1a3	-	Homo sapiens
RalDH1	isoform	Homo sapiens
RALDH2	isoform	Homo sapiens
RALDH3	isoform	Homo sapiens
retinaldehyde dehydrogenase	-	Homo sapiens
retinaldehyde dehydrogenase 1	-	Homo sapiens
retinaldehyde dehydrogenase 2	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)