Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells | Gallus gallus |
expressed in HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dichloro-all-trans-retinone | irreversible inhibitor that effectively inhibits isoform RALDH1 in the nanomolar range. I.e. (3E,5E,7E,9E)-1,1-dichloro-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,5,7,9-tetraen-2-one; irreversible inhibitor that effectively inhibits isoforms RALDH2 in the nanomolar range. I.e. (3E,5E,7E,9E)-1,1-dichloro-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,5,7,9-tetraen-2-one; irreversible inhibitor that effectively inhibits isoforms RALDH3 in the nanomolar range. I.e. (3E,5E,7E,9E)-1,1-dichloro-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,5,7,9-tetraen-2-one | Gallus gallus | |
dichloro-all-trans-retinone | irreversible inhibitor that effectively inhibits isoform RALDH2 in the nanomolar range. I.e. (3E,5E,7E,9E)-1,1-dichloro-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,5,7,9-tetraen-2-one | Homo sapiens | |
WIN 18446 | - |
Gallus gallus | |
WIN 18446 | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0807 | - |
retinal | isoform RALDH2, at pH 8.2 and 25°C | Gallus gallus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
retinal + NAD+ + H2O | Gallus gallus | - |
all-trans-retinoate + NADH + 2 H+ | - |
? | |
retinal + NAD+ + H2O | Homo sapiens | - |
all-trans-retinoate + NADH + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Gallus gallus | O93344 | - |
- |
Gallus gallus | P27463 | - |
- |
Homo sapiens | O94788 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
retinal + NAD+ + H2O | - |
Gallus gallus | all-trans-retinoate + NADH + 2 H+ | - |
? | |
retinal + NAD+ + H2O | - |
Homo sapiens | all-trans-retinoate + NADH + 2 H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALDH1A1 | - |
Gallus gallus |
Aldh1a2 | - |
Homo sapiens |
Aldh1a2 | - |
Gallus gallus |
Aldh1a3 | - |
Gallus gallus |
RalDH1 | isoform | Gallus gallus |
RALDH2 | isoform | Homo sapiens |
RALDH2 | isoform | Gallus gallus |
RALDH3 | isoform | Gallus gallus |
retinaldehyde dehydrogenase | - |
Gallus gallus |
retinaldehyde dehydrogenase 1 | - |
Gallus gallus |
retinaldehyde dehydrogenase 2 | - |
Homo sapiens |
retinaldehyde dehydrogenase 2 | - |
Gallus gallus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Gallus gallus | |
NAD+ | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000051 | - |
dichloro-all-trans-retinone | isoform RALDH2, at pH 8.2 and 25°C | Gallus gallus | |
0.00000674 | - |
dichloro-all-trans-retinone | isoform RALDH3, at pH 8.2 and 25°C | Gallus gallus | |
0.00006435 | - |
dichloro-all-trans-retinone | isoform RALDH2, at pH 8.2 and 25°C | Homo sapiens | |
0.0001944 | - |
dichloro-all-trans-retinone | isoform RALDH1, at pH 8.2 and 25°C | Gallus gallus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000055 | - |
isoform RALDH2, at pH 8.2 and 25°C | Gallus gallus | dichloro-all-trans-retinone | |
0.00016127 | - |
isoform RALDH3, at pH 8.2 and 25°C | Gallus gallus | dichloro-all-trans-retinone | |
0.00019132 | - |
isoform RALDH2, at pH 8.2 and 25°C | Homo sapiens | dichloro-all-trans-retinone | |
0.0004347 | - |
isoform RALDH1, at pH 8.2 and 25°C | Gallus gallus | dichloro-all-trans-retinone |