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Literature summary for 1.2.1.36 extracted from

  • Ito, K.; Zolfaghari, R.; Hao, L.; Ross, A.C.
    Inflammation rapidly modulates the expression of ALDH1A1 (RALDH1) and vimentin in the liver and hepatic macrophages of rats in vivo (2014), Nutr. Metab., 11, 54 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.36

Application

Application Comment Organism
diagnostics ALDH1A1 is rapidly gaining importance as a stem cell marker Rattus norvegicus
molecular biology ALDH1A1 is rapidly gaining importance as a stem cell marker Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
gene Aldh1a1, quantitative reverse transcription PCR enzyme expression analysis Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information ALDH1A1 may have a broad cellular distribution in the liver, in situ hybridization Rattus norvegicus
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
all-trans-retinal + NAD+ + H2O Rattus norvegicus
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 all-trans-retinoate + NADH + 2 H+
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P51647
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-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte ALDH1A1 protein exhibits diffuse staining in hepatocytes, with greater intensity in the periportal region including surrounding bile ducts Rattus norvegicus
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liver ALDH1A1 is most highly expressed ALDH1 gene in liver Rattus norvegicus
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macrophage hepatic Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinal + NAD+ + H2O
-
 Rattus norvegicus all-trans-retinoate + NADH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
ALDH1A1
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 Rattus norvegicus
RALDH
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 Rattus norvegicus
RALDH1A1
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 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus inflammation reduces ALDH1A1 mRNA in whole liver regardless of the level of vitamin A in the diet, while treatment with retinal reduces ALDH1A1 expression only in chow-fed rats. Acute inflammation rapidly downregulates ALDH1A1 expression in whole liver down
Rattus norvegicus acute inflammation rapidly increases the enzyme expression in periportal macrophages up

General Information

General Information Comment Organism
evolution the enzyme is a member of the ALDH1 protein family Rattus norvegicus
malfunction acute inflammation rapidly downregulates ALDH1A1 expression in whole liver while increasing its expression in periportal macrophages Rattus norvegicus
physiological function changes in ALDH1A1 expression appear to be part of the early acute-phase inflammatory response, which alters the expression of other retinoid homeostatic genes Rattus norvegicus