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Literature summary for 1.2.1.36 extracted from
- Regulation of retinal dehydrogenases and retinoic acid synthesis by cholesterol metabolites (2006), EMBO J., 25, 3203-3213.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cholesterol | - |
Mus musculus |  |
| additional information | 22(R)-hydroxy cholesterol elevates significantly the RALDH2 mRNA level in H2.35 cells | Mus musculus | |
| additional information | dexamethasone, little effect on RALDH expression | Mus musculus | |
| additional information | oxysterols, cholesterol metabolites, induce the RALDH1 gene via upregulation of sterol regulatory element binding protein-1c, SREBP-1c | Mus musculus | |
| additional information | oxysterols, cholesterol metabolites, induce the RALDH2 gene via upregulation of sterol regulatory element binding protein-1c, SREBP-1c | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-1 cells | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| pravastatin sodium | cholesterol-lowering agent downregulates the expression of RALDH1,2 genes | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| retinal + NAD+ + H2O | Mus musculus | - |
retinoate + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| H2.35 cell | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| Neuro-2a cell | - |
Mus musculus | - |
| P-19 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| retinal + NAD+ + H2O | - |
Mus musculus | retinoate + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RalDH1 | - |
Mus musculus |
| RALDH2 | - |
Mus musculus |
| Retinal dehydrogenase | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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