Cloned (Comment) | Organism |
---|---|
cloning of lys2, the cloned gene encodes a functional alpha-aminoadipate reductase as shown by complementation of a Penicillium chrysogenum lys2 mutant, the aminoacid sequence shows strong homology with the alpha-aminoadipate reductase encoded by lys2 genes of Candida albicans, Schizosaccharomyces pombe, Saccharomyces cerevisiae and Penicillium chrysogenum | Acremonium chrysogenum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alpha-aminoadipate + NAD(P)H | Acremonium chrysogenum | - |
L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
additional information | Acremonium chrysogenum | the enzyme catalyzes both the activation of alpha-aminoadipic acid and its reduction to semialdehyde | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acremonium chrysogenum | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | the lys5 gene product is functionally active and can recognize apo-Lys2, transferring a 4'-phosphopantetheinyl moiety to the conserved serine residue in the peptidyl carrier domain of the protein | Acremonium chrysogenum |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Acremonium chrysogenum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-2-aminoadipate + NADPH | - |
Acremonium chrysogenum | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
L-alpha-aminoadipate + NAD(P)H | - |
Acremonium chrysogenum | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
additional information | the enzyme catalyzes both the activation of alpha-aminoadipic acid and its reduction to semialdehyde | Acremonium chrysogenum | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | reaction not observed | Acremonium chrysogenum | |
NADPH | - |
Acremonium chrysogenum |