Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Alda-1 | acts as activator at high concentrations of aldehyde | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Alda-1 | acts as inhibitor at low concentrations of aldehyde | Homo sapiens | |
NADH | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0007 | - |
propanal | in the absence of Alda-1, at pH 7.4 and 25°C | Homo sapiens | |
0.006 | - |
propanal | in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C | Homo sapiens | |
0.03 | - |
NAD+ | in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C | Homo sapiens | |
0.073 | - |
NAD+ | in the absence of Alda-1, at pH 7.4 and 25°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
nickel chelating Sepharose column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
propanal + NAD+ + H2O | - |
Homo sapiens | propanoate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALDH2 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.9 | - |
NAD+ | in the absence of Alda-1, at pH 7.4 and 25°C | Homo sapiens | |
1.9 | - |
propanal | in the absence of Alda-1, at pH 7.4 and 25°C | Homo sapiens | |
3.05 | - |
NAD+ | in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C | Homo sapiens | |
3.05 | - |
propanal | in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.053 | - |
NADH | in the absence of Alda-1, at pH 7.4 and 25°C | Homo sapiens | |
0.133 | - |
NADH | in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.027 | - |
NAD+ | in the absence of Alda-1, at pH 7.4 and 25°C | Homo sapiens | |
0.117 | - |
NAD+ | in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C | Homo sapiens | |
0.517 | - |
propanal | in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C | Homo sapiens | |
3.13 | - |
propanal | in the absence of Alda-1, at pH 7.4 and 25°C | Homo sapiens |