Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.3 extracted from

  • Khanna, M.; Chen, C.H.; Kimble-Hill, A.; Parajuli, B.; Perez-Miller, S.; Baskaran, S.; Kim, J.; Dria, K.; Vasiliou, V.; Mochly-Rosen, D.; Hurley, T.D.
    Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases (2011), J. Biol. Chem., 286, 43486-43494.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.3

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
isoform ALDH2, using 100 mM Na-ACES buffer, pH 6.4-6.6, 100 mM guanidine-HCl, 10 mM MgCl2, and 4 mM dithiothreitol and 16-17% (w/v) PEG 6000 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone
-
 Homo sapiens
3-(1-azepanyl)-1-phenyl-1-propanone
-
 Homo sapiens
3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone
-
 Homo sapiens
3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, column chromatography, and gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
propionaldehyde + NAD+ + H2O
-
 Homo sapiens propionate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
ALD1A1 isoform Homo sapiens
ALDH2 isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0022
-
 isoform ALDH1A1, pH and temperature not specified in the publication Homo sapiens 3-(1-azepanyl)-1-phenyl-1-propanone
0.0025
-
 isoform ALDH1A1, pH and temperature not specified in the publication Homo sapiens 3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone
0.0054
-
 isoform ALDH2, pH and temperature not specified in the publication Homo sapiens 3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone
0.0064
-
 isoform ALDH2, pH and temperature not specified in the publication Homo sapiens 3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone
0.0068
-
 isoform ALDH1A1, pH and temperature not specified in the publication Homo sapiens 1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone
0.0079
-
 isoform ALDH1A1, pH and temperature not specified in the publication Homo sapiens 3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone
0.0083
-
 isoform ALDH2, pH and temperature not specified in the publication Homo sapiens 1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone
0.0086
-
 isoform ALDH2, pH and temperature not specified in the publication Homo sapiens 3-(1-azepanyl)-1-phenyl-1-propanone