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Literature summary for 1.2.1.3 extracted from

  • Stagos, D.; Chen, Y.; Cantore, M.; Jester, J.V.; Vasiliou, V.
    Corneal aldehyde dehydrogenases: multiple functions and novel nuclear localization (2010), Brain Res. Bull., 81, 211-218.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.3

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
cytoplasm isoform ALDH3A1 Oryctolagus cuniculus 5737
-
nucleus
-
 Mus musculus 5634
-
nucleus isoform ALDH3A1 Oryctolagus cuniculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxy-2-nonenal + NAD+ + H2O Oryctolagus cuniculus
-
 4-hydroxynon-2-enoate + NADH + H+
-
 ?
4-hydroxy-2-nonenal + NAD+ + H2O Mus musculus
-
 4-hydroxynon-2-enoic acid + NADH
-
 ?
4-hydroxy-2-nonenal + NAD+ + H2O Mus musculus poor substrate of isoform ALDH3A1 4-hydroxynon-2-enoic acid + NADH
-
 ?
malondialdehyde + NAD+ + H2O Mus musculus
-
 ?
-
 ?
malondialdehyde + NAD+ + H2O Oryctolagus cuniculus poor substrate of isoform ALDH3A1 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P47738 isoform ALDH2
-
Mus musculus Q3UNF5 isoform ALDH3A1
-
Mus musculus Q9CZS1 isoform ALDH1B1
-
Mus musculus Q9DBF1 isoform ALDH7A1
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cornea
-
 Mus musculus
-
keratocyte
-
 Oryctolagus cuniculus
-
lens
-
 Mus musculus
-
TRK-43 cell
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxy-2-nonenal + NAD+ + H2O
-
 Oryctolagus cuniculus 4-hydroxynon-2-enoate + NADH + H+
-
 ?
4-hydroxy-2-nonenal + NAD+ + H2O
-
 Mus musculus 4-hydroxynon-2-enoic acid + NADH
-
 ?
4-hydroxy-2-nonenal + NAD+ + H2O poor substrate of isoform ALDH3A1 Mus musculus 4-hydroxynon-2-enoic acid + NADH
-
 ?
malondialdehyde + NAD+ + H2O
-
 Mus musculus ?
-
 ?
malondialdehyde + NAD+ + H2O poor substrate of isoform ALDH3A1 Oryctolagus cuniculus ?
-
 ?

Subunits

Subunits Comment Organism
homodimer isoform ALDH3A1 Oryctolagus cuniculus
homodimer isoform ALDH3A1 Mus musculus
homotetramer isoform ALDH1B1 Mus musculus

Synonyms

Synonyms Comment Organism
Aldh1b1 isoform, formerly known as ALDHx or ALDH5 Mus musculus
ALDH2 isoform Mus musculus
ALDH3A1 isoform Oryctolagus cuniculus
ALDH3A1 isoform Mus musculus
Aldh7a1 isoform Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Oryctolagus cuniculus
NAD+
-
 Mus musculus

Expression

Organism Comment Expression
Oryctolagus cuniculus isoform ALDH3A1 protein and mRNA levels increase substantially in mouse cornea by postnatal day 14 up
Mus musculus isoform ALDH3A1 protein and mRNA levels increase substantially in mouse cornea by postnatal day 14 up

General Information

General Information Comment Organism
malfunction decreased ALDH3A1 activity is associated with pathologic corneas (cataract development) Oryctolagus cuniculus
malfunction decreased ALDH3A1 activity is associated with pathologic corneas (cataract development) Mus musculus
metabolism isoform ALDH3A1 may exhibit antioxidant activity indirectly by producing NADH during metabolism Oryctolagus cuniculus
metabolism isoform ALDH3A1 may exhibit antioxidant activity indirectly by producing NADH during metabolism Mus musculus
physiological function isoform ALDH1A1 plays a protective role against ultraviolet radiation-induced oxidative damage to ocular tissues Mus musculus
physiological function isoform ALDH3A1 plays a protective role against ultraviolet radiation-induced oxidative damage to ocular tissues. The nuclear presence of isoform ALDH3A1 may be involved in cell cycle regulation Mus musculus
physiological function isoforms ALDH3A1 plays a protective role against ultraviolet radiation-induced oxidative damage to ocular tissues. The nuclear presence of isoform ALDH3A1 may be involved in cell cycle regulation Oryctolagus cuniculus