Literature summary for 1.2.1.3 extracted from

Chiang, C.P.; Wu, C.W.; Lee, S.P.; Chung, C.C.; Wang, C.W.; Lee, S.L.; Nieh, S.; Yin, S.J.
Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: implications for pathogenesis of alcohol-induced pancreatic injury (2009), Alcohol. Clin. Exp. Res., 33, 1059-1068.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
cyanamide	complete inhibition at 0.5 mM	Homo sapiens
additional information	inclusion of protease inhibitors, 1 mM benzamidine and 1 mM phenylmethylsulfonyl fluoride, in preparation of homogenate supernatants slightly inhibit ALDH activity	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
54000	-	isoform ALDH3A1, SDS-PAGE	Homo sapiens
55000	-	isoforms ALDH1A1 and ALDH2, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	the activities of ALDH1A1 and ALDH2 are detected in the acini and islets, particularly prominent in the ductal cells. There is extremely low protein content of ALDH3A1 in pancreas	Homo sapiens	-

Storage Stability

Storage Stability	Organism
-70°C, liquid nitrogen, 6 months, the enzyme remains stable	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetaldehyde + NAD+ + H2O	-	Homo sapiens	acetate + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
ALDH	-	Homo sapiens
ALDH1A1	isoform	Homo sapiens
ALDH2	isoform	Homo sapiens
ALDH3A1	isoform	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)