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Literature summary for 1.2.1.3 extracted from

  • Badawy, A.A.; Morgan, C.J.
    Tryptophan metabolites as potent inhibitors of aldehyde dehydrogenase activity and potential alcoholism-aversion therapeutic agents (2007), Int. Congr. Ser., 1304, 344-351.
No PubMed abstract available
Search for more literature for 1.2.1.3

Inhibitors

Inhibitors Comment Organism Structure
3-hydroxyanthranilic acid 46% inhibition at 0.002 mM Rattus norvegicus
3-hydroxykynurenine 55% inhibition at 0.002 mM Rattus norvegicus
5-hydroxytryptophan 23% inhibition at 0.1 mM Saccharomyces cerevisiae
Disulfiram 42% inhibition at 0.002 mM Rattus norvegicus
Disulfiram 72% inhibition at 0.002 mM Saccharomyces cerevisiae
harman 18% inhibition at 0.1 mM Saccharomyces cerevisiae
indol-3-ylpyruvic acid 30% inhibition at 0.002 mM Rattus norvegicus
indol-3-ylpyruvic acid 55% inhibition at 0.002 mM Saccharomyces cerevisiae
Kynurenic acid 40% inhibition at 0.002 mM Rattus norvegicus
kynurenine 24% inhibition at 0.1 mM Saccharomyces cerevisiae
norharman 23% inhibition at 0.1 mM Saccharomyces cerevisiae
xanthurenic acid 56% inhibition at 0.1 mM Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-
mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O
-
 Rattus norvegicus acetate + NADH + H+
-
 ?
acetaldehyde + NAD+ + H2O
-
 Saccharomyces cerevisiae acetate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
ALDH
-
 Rattus norvegicus
ALDH
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rattus norvegicus
NAD+
-
 Saccharomyces cerevisiae