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Literature summary for 1.2.1.3 extracted from

  • Marchitti, S.A.; Deitrich, R.A.; Vasiliou, V.
    Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase (2007), Pharmacol. Rev., 59, 125-150.
    View publication on PubMed
Search for more literature for 1.2.1.3

Inhibitors

Inhibitors Comment Organism Structure
Disulfiram 0.01 mM; 0.01 mM; 0.01 mM; 0.01 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0004
-
 3,4-dihydroxyphenylacetaldehyde isozyme ALDH1A1 from liver Homo sapiens
0.001
-
 3,4-dihydroxyphenylacetaldehyde isozyme ALDH2 from liver Homo sapiens
0.0042
-
 3,4-dihydroxyphenylacetaldehyde isozyme ALDH1A1 from brain Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P05091
-
-
Homo sapiens P30837
-
-
Homo sapiens Q9H2A2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O
-
 Homo sapiens 3,4-dihydroxyphenylacetate + NADH + H+
-
 ?
3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O
-
 Homo sapiens 3,4-dihydroxyphenylglycolate + NADH + H+
-
 ?
acetaldehyde + NAD+ + H2O
-
 Homo sapiens acetate + NADH + H+
-
 ?
acetaldehyde + NAD+ + H2O preferred substrate of isozyme ALDH2 Homo sapiens acetate + NADH + H+
-
 ?
retinal + NAD+ + H2O
-
 Homo sapiens retinoic acid + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
ALDH1A1
-
 Homo sapiens
Aldh1b1
-
 Homo sapiens
ALDH2
-
 Homo sapiens
Aldh8a1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ required Homo sapiens