Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosine 5'-monophosphate | competitive with NAD+ and noncompetitive with acetaldehyde | Homo sapiens | |
Chloral hydrate | competitive with respect to acetaldehyde | Homo sapiens | |
Disulfiram | strong inhibition of isoenzyme 1, no inhibition of isoenzyme 2 | Homo sapiens | |
NADH | competitive with NAD+ at high and low concentrations of acetaldehyde, product inhibitor | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | 0.003 | acetaldehyde | isoenzyme 2 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
enzyme I and II | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
an aldehyde + NAD+ + H2O = a carboxylate + NADH + H+ | mechanism proceeds mainly through an enzyme*NAD+ binary complex, but at high concentrations of acetaldehyde a small degree of randomness is observed, the rate-limiting step of the dehydrogenase reaction occurs after ternary complex interconversion | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |