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Literature summary for 1.2.1.3 extracted from
- Aldehyde dehydrogenases from liver (1981), Methods Enzymol., 71, 772-781.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
acetaldehyde | isoenzyme F2 | Equus caballus |  |
| 0.003 | - |
acetaldehyde | isoenzyme E2 | Homo sapiens | |
| 0.003 | - |
NAD+ | isoenzyme F1 | Equus caballus | |
| 0.0125 | - |
NAD+ | cytoplasmic isoenzyme | Ovis aries | |
| 0.03 | - |
NAD+ | isoenzyme F2 | Equus caballus | |
| 0.03 | - |
acetaldehyde | isoenzyme E1 | Homo sapiens | |
| 0.04 | - |
NAD+ | isoenzyme E1 | Homo sapiens | |
| 0.07 | - |
NAD+ | isoenzyme E2 | Homo sapiens | |
| 0.07 | - |
acetaldehyde | isoenzyme F1 | Equus caballus | |
| 0.077 | - |
NAD+ | mitochondrial isoenzyme | Ovis aries | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| cytoplasm | - |
Ovis aries | 5737 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| mitochondrion | - |
Ovis aries | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
x * 52000, isoenzyme F1 | Equus caballus |
| 53000 | - |
4 * 53000, SDS-PAGE | Ovis aries |
| 53000 | - |
x * 53000, isoenzyme F2 | Equus caballus |
| 54000 | - |
x * 54000, isoenzyme E1 and E2 | Homo sapiens |
| 205000 | - |
mitochondrial enzyme, gel filtration | Ovis aries |
| 212000 | - |
cytoplasmic enzyme, gel filtration | Ovis aries |
| 225000 | - |
- |
Homo sapiens |
| 230000 | - |
- |
Equus caballus |
| 230000 | - |
isoenzyme E2 | Homo sapiens |
| 240000 | - |
isoenzyme F2 | Equus caballus |
| 245000 | - |
isoenzyme E1 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Equus caballus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Ovis aries | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Equus caballus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Ovis aries | - |
| liver | - |
Equus caballus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.37 | - |
isoenzyme F1 | Equus caballus |
| 0.54 | - |
isoenzyme E1 | Homo sapiens |
| 0.8 | - |
isoenzyme F2 | Equus caballus |
| 1.3 | - |
isoenzyme E2 | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetaldehyde + NAD+ + H2O | - |
Homo sapiens | acetate + NADH + H+ | - |
ir | |
| acetaldehyde + NAD+ + H2O | - |
Ovis aries | acetate + NADH + H+ | - |
ir | |
| acetaldehyde + NAD+ + H2O | - |
Equus caballus | acetate + NADH + H+ | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 53000, isoenzyme F2 | Equus caballus |
| ? | x * 52000, isoenzyme F1 | Equus caballus |
| ? | x * 54000, isoenzyme E1 and E2 | Homo sapiens |
| tetramer | - |
Homo sapiens |
| tetramer | 4 * 53000, SDS-PAGE | Ovis aries |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.6 | - |
isoenzyme E1 | Homo sapiens |
| 9.5 | - |
isoenzyme E2 | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
| NAD+ | - |
Ovis aries | |
| NAD+ | - |
Equus caballus | |
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Release 2023.1 (January 2023)
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