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Literature summary for 1.2.1.3 extracted from
- Bovine lens aldehyde dehydrogenase. Kinetics and mechanism (1983), Biochem. J., 215, 361-368.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetate | - |
Bos taurus |  |
| ADPribose | - |
Bos taurus | |
| Chloral hydrate | - |
Bos taurus | |
| Disulfiram | - |
Bos taurus | |
| NADH | competitive with respect to NAD+, non-competitive with respect to acetaldehyde | Bos taurus | |
| PCMB | - |
Bos taurus | |
| thio-NAD+ | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0034 | - |
p-nitrobenzaldehyde | - |
Bos taurus | |
| 0.00352 | - |
phenylacetaldehyde | - |
Bos taurus | |
| 0.0043 | - |
4-nitrophenyl acetate | - |
Bos taurus | |
| 0.0218 | - |
propanal | - |
Bos taurus | |
| 0.13 | - |
malondialdehyde | - |
Bos taurus | |
| 0.372 | - |
glyceraldehyde 3-phosphate | - |
Bos taurus | |
| 0.39 | - |
glyceraldehyde | - |
Bos taurus | |
| 0.4 | - |
acetaldehyde | - |
Bos taurus | |
| 0.69 | - |
glycolaldehyde | - |
Bos taurus | |
| 3.54 | - |
Succinic semialdehyde | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Bos taurus | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| an aldehyde + NAD+ + H2O = a carboxylate + NADH + H+ | compulsory ordered ternary-complex mechanism with NAD+ binding before acetaldehyde | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lens | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl acetate + H2O | - |
Bos taurus | 4-nitrophenol + acetate | - |
r | |
| acetaldehyde + NAD+ + H2O | - |
Bos taurus | acetate + NADH + H+ | - |
? | |
| glyceraldehyde + NAD+ + H2O | - |
Bos taurus | glycerate + NADH | - |
? | |
| glyceraldehyde 3-phosphate + NAD+ + H2O | - |
Bos taurus | glycerate 3-phosphate + NADH | - |
? | |
| glycolaldehyde + NAD+ + H2O | - |
Bos taurus | glycolate + NADH | - |
? | |
| malondialdehyde + NAD+ + H2O | - |
Bos taurus | ? + NADH | - |
? | |
| additional information | the enzyme also catalyzes esterase reaction with p-nitrophenylacetate + H2O | Bos taurus | ? | - |
? | |
| p-nitrobenzaldehyde + NAD+ + H2O | - |
Bos taurus | p-nitrobenzoate + NADH | - |
? | |
| phenylacetaldehyde + NAD+ + H2O | - |
Bos taurus | phenylacetate + NADH + H+ | - |
? | |
| propanal + NAD+ + H2O | - |
Bos taurus | propionate + NADH | - |
? | |
| succinic semialdehyde + NAD+ + H2O | - |
Bos taurus | succinate + NADH | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.23 | - |
p-nitrobenzaldehyde | - |
Bos taurus | |
| 0.26 | - |
4-nitrophenyl acetate | - |
Bos taurus | |
| 0.28 | - |
glyceraldehyde 3-phosphate | - |
Bos taurus | |
| 0.76 | - |
Succinic semialdehyde | - |
Bos taurus | |
| 1.19 | - |
malondialdehyde | - |
Bos taurus | |
| 1.2 | - |
glycolaldehyde | - |
Bos taurus | |
| 1.29 | - |
glyceraldehyde | - |
Bos taurus | |
| 1.39 | - |
phenylacetaldehyde | - |
Bos taurus | |
| 1.85 | - |
propanal | - |
Bos taurus | |
| 1.86 | - |
acetaldehyde | - |
Bos taurus | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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