BRENDA - Enzyme Database show
show all sequences of 1.2.1.24

Succinic semialdehyde dehydrogenase: purification and properties of the enzyme from monkey brain

Albers, R.W.; Koval, G.J.; Biochim. Biophys. Acta 52, 29-35 (1961)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
sodium lauryl sulfate
low concentrations activate to a small extent
Platyrrhini
General Stability
General Stability
Organism
denaturation by sodium lauryl sulfate
Platyrrhini
NAD+ and mercaptoethanol effectively protect from auto-oxidation. NAD+ does not prevent auto-oxidation in presence of urea
Platyrrhini
Inhibitors
Inhibitors
Commentary
Organism
Structure
4-hydroxybenzaldehyde
-
Platyrrhini
arsenite
-
Platyrrhini
m-hydroxybenzaldehyde
-
Platyrrhini
NEM
-
Platyrrhini
p-chloromercuriphenyl sulfonate
-
Platyrrhini
succinate semialdehyde
substrate inhibition above 0.02 mM
Platyrrhini
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Platyrrhini
-
-
-
Purification (Commentary)
Commentary
Organism
-
Platyrrhini
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Platyrrhini
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
succinate semialdehyde + NAD+ + H2O
-
288170
Platyrrhini
succinate + NADH
-
-
-
?
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
50
-
pH 7.4, 8 min, complete inactivation. Mercaptoethanol stabilizes for 20 min or longer
Platyrrhini
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.7
9.1
-
Platyrrhini
pH Range
pH Minimum
pH Maximum
Commentary
Organism
additional information
-
-
Platyrrhini
Cofactor
Cofactor
Commentary
Organism
Structure
3-acetylpyridine adenine dinucleotide
reduced at nearly the same rate as NAD+
Platyrrhini
deamino-NAD+
reduced at nearly the same rate as NAD+
Platyrrhini
NAD+
-
Platyrrhini
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
sodium lauryl sulfate
low concentrations activate to a small extent
Platyrrhini
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
3-acetylpyridine adenine dinucleotide
reduced at nearly the same rate as NAD+
Platyrrhini
deamino-NAD+
reduced at nearly the same rate as NAD+
Platyrrhini
NAD+
-
Platyrrhini
General Stability (protein specific)
General Stability
Organism
denaturation by sodium lauryl sulfate
Platyrrhini
NAD+ and mercaptoethanol effectively protect from auto-oxidation. NAD+ does not prevent auto-oxidation in presence of urea
Platyrrhini
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
4-hydroxybenzaldehyde
-
Platyrrhini
arsenite
-
Platyrrhini
m-hydroxybenzaldehyde
-
Platyrrhini
NEM
-
Platyrrhini
p-chloromercuriphenyl sulfonate
-
Platyrrhini
succinate semialdehyde
substrate inhibition above 0.02 mM
Platyrrhini
Purification (Commentary) (protein specific)
Commentary
Organism
-
Platyrrhini
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Platyrrhini
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
succinate semialdehyde + NAD+ + H2O
-
288170
Platyrrhini
succinate + NADH
-
-
-
?
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
50
-
pH 7.4, 8 min, complete inactivation. Mercaptoethanol stabilizes for 20 min or longer
Platyrrhini
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.7
9.1
-
Platyrrhini
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
additional information
-
-
Platyrrhini
Other publictions for EC 1.2.1.24
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742640
Kumar
Characterization of succinic ...
Aspergillus niger, Aspergillus niger NCIM 565
Indian J. Exp. Biol.
53
67-74
2015
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7
3
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1
2
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2
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1
1
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1
1
1
4
1
1
-
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-
1
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2
8
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2
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7
8
3
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1
2
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1
-
1
1
1
4
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
743762
Tamazian
Modeling conformational redox ...
Homo sapiens
Proteins
83
2217-2229
2015
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1
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1
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1
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1
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2
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2
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1
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1
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1
1
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2
2
-
-
-
722211
Esser
Unraveling the function of par ...
Saccharolobus solfataricus
Extremophiles
17
205-216
2013
-
-
1
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-
3
3
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3
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4
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1
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3
1
1
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3
1
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1
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1
1
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3
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3
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3
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1
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-
3
1
1
-
-
3
1
-
-
-
-
-
-
-
3
3
741570
Puettmann
A novel ALDH5A1 mutation is a ...
Homo sapiens
Am. J. Med. Genet. A
161A
1915-1922
2013
-
-
1
-
1
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1
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1
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3
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-
1
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-
1
-
1
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1
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-
1
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1
1
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1
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1
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1
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1
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-
1
-
1
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-
1
-
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-
-
1
1
-
-
-
710898
Kim
Succinic semialdehyde dehydrog ...
Homo sapiens, Mus musculus
Antioxid. Redox Signal.
15
691-718
2011
-
-
-
2
7
-
-
4
2
-
2
4
-
5
2
-
-
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-
8
-
-
4
2
-
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-
2
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2
2
7
-
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4
2
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2
4
-
2
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-
8
-
-
4
2
-
-
-
-
-
-
-
-
-
4
4
-
-
-
710394
Langendorf
The X-ray crystal structure of ...
Homo sapiens
PLoS One
5
e9280
2010
-
-
-
-
14
-
-
-
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-
1
-
1
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-
-
-
1
-
-
-
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-
-
-
-
1
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-
-
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-
1
-
14
-
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-
-
-
1
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-
-
1
-
-
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-
1
1
-
-
-
697282
Swenby
The conserved R166 residue of ...
Rattus norvegicus
Chem. Biol. Interact.
178
70-74
2009
-
-
1
-
4
-
-
14
-
-
-
-
-
2
-
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-
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-
-
-
2
-
-
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1
1
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1
1
-
4
-
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-
14
-
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-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
698174
Malaspina
Comparative genomics of aldehy ...
Homo sapiens
Hum. Genomics
3
106-120
2009
-
-
-
-
4
-
-
-
-
-
-
2
-
3
-
-
-
-
-
1
-
-
2
-
-
-
-
-
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-
-
1
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1
-
4
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-
2
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1
-
-
2
-
-
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-
-
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-
699375
Pearl
Succinic semialdehyde dehydrog ...
Homo sapiens, Mus musculus
J. Inherit. Metab. Dis.
32
343-352
2009
-
-
-
-
-
-
-
-
-
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-
2
-
2
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2
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2
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2
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2
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-
2
-
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-
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-
699376
Kratz
Sensory integration interventi ...
Homo sapiens
J. Inherit. Metab. Dis.
32
353-360
2009
-
-
-
-
-
-
-
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1
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-
699382
Di Rosa
Visual evoked potentials in su ...
Homo sapiens
J. Inherit. Metab. Dis.
32
S201-S205
2009
-
-
-
-
1
-
-
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1
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700444
Pearl
Decreased GABA-A binding on FM ...
Homo sapiens
Neurology
73
423-429
2009
-
1
-
-
-
-
-
-
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1
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692615
Rothacker
Functional characterization of ...
Drosophila melanogaster
Insect Biochem. Mol. Biol.
38
354-366
2008
-
-
1
-
9
-
-
6
-
-
1
-
-
1
-
-
1
-
-
-
-
1
8
1
1
-
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-
-
1
-
2
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-
1
2
-
9
-
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-
-
6
-
-
1
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-
1
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-
1
8
1
1
-
-
-
-
1
-
-
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-
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-
692620
Rothacker
Molecular cloning, partial gen ...
Ctenocephalides felis, Lucilia cuprina
Insect Mol. Biol.
17
279-291
2008
-
2
2
-
-
-
2
16
-
-
4
-
-
2
-
-
-
-
-
-
-
-
12
-
-
-
-
-
1
1
-
4
-
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-
-
2
2
4
-
-
-
-
2
-
16
-
-
4
-
-
-
-
-
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-
-
-
12
-
-
-
-
-
1
1
-
-
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-
696968
Jansen
Neurotransmitter alterations i ...
Mus musculus
BMC Dev. Biol.
8
112
2008
-
-
-
-
-
-
-
-
-
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-
1
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1
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1
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1
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697443
Knerr
Neuropsychiatric morbidity in ...
Homo sapiens
CNS Spectr.
13
598-605
2008
-
-
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1
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697675
Stewart
Circadian distribution of gene ...
Mus musculus
Epilepsy Behav.
13
290-294
2008
-
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5
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697805
Nylen
A ketogenic diet rescues the m ...
Mus musculus
Exp. Neurol.
210
449-457
2008
-
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700082
Rothacker
Succinic semialdehyde dehydrog ...
Mus musculus, Rhipicephalus microplus
Mol. Biochem. Parasitol.
161
32-43
2008
-
-
2
-
-
-
8
29
-
-
2
-
-
2
-
-
2
-
-
2
-
-
51
-
-
-
-
-
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-
3
-
-
4
-
-
2
3
-
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-
4
8
-
29
-
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2
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2
-
2
-
-
51
-
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700887
Ludewig
Mutants of GABA transaminase ( ...
Arabidopsis thaliana
PLoS ONE
3
e3383
2008
-
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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689379
Marchitti
Neurotoxicity and metabolism o ...
Homo sapiens
Pharmacol. Rev.
59
125-150
2007
-
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1
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1
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1
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2
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1
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690435
Leone
A human derived SSADH coding v ...
Homo sapiens
Ann. Hum. Biol.
33
593-603
2007
-
1
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3
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692836
Fuhrer
Computational prediction and e ...
Escherichia coli, Escherichia coli BW25113
J. Bacteriol.
189
8073-8078
2007
1
1
1
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1
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1
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Plant succinic semialdehyde de ...
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288169
Kumar
Inhibition of succinic semiald ...
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Molecular cloning of the matur ...
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8
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Koh
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Purification and properties of ...
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288150
Satya Narayan
Potato tuber succinate semiald ...
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2
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288151
Yamaura
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Purification and some properti ...
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52
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2
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1
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1
1
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2
1
1
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1
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1
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1
2
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2
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7
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2
1
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1
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288152
Ryzlak
Human brain high Km aldehyde d ...
Homo sapiens
Arch. Biochem. Biophys.
266
386-396
1988
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1
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1
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6
1
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1
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288153
Ferrer
-
a single succinic semialdehyde ...
Klebsiella pneumoniae, Klebsiella pneumoniae M5a1
FEMS Microbiol. Lett.
52
161-164
1988
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6
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288154
Marek
Cloning and expression of the ...
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1988
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1
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288155
Sims
Degradation of pyridine by Mic ...
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Appl. Environ. Microbiol.
51
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1986
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1
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288156
Hearl
Interactions between 4-aminobu ...
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1984
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2
1
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1
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1
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2
1
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288157
Galleschi
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Succinic semialdehyde dehydrog ...
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Biochem. Physiol. Pflanz.
178
645-651
1983
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2
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Rivett
Kinetic studies with rat-brain ...
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288159
Donnelly
Two succinic semialdehyde dehy ...
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J. Bacteriol.
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1425-1427
1981
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The binding of NADH to succini ...
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1980
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Separation and characterizatio ...
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Enzymes of agmatine degradatio ...
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-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
288161
Lai
Preparation of synaptic and no ...
Rattus norvegicus
Methods Enzymol.
55
51-60
1979
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
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-
-
1
-
-
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-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288163
Blaner
Succinic semialdehyde dehydrog ...
Sus scrofa
J. Biol. Chem.
254
1794-1798
1979
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
1
-
-
1
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
288164
Galleschi
Succinic semialdehyde dehydrog ...
Triticum turgidum subsp. durum
Planta
142
175-180
1978
1
-
-
-
-
-
-
2
-
-
1
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-
1
-
-
-
-
-
-
1
-
2
-
-
-
1
-
1
1
2
2
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
1
-
2
-
-
-
1
-
1
1
2
-
-
-
-
-
-
-
288165
Cash
Purification and properties of ...
Homo sapiens
Biochim. Biophys. Acta
524
26-36
1978
-
-
-
-
-
-
2
1
-
-
2
-
-
1
-
-
1
-
-
1
-
-
2
1
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
2
-
1
-
-
2
-
-
-
-
1
-
1
-
-
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
288166
Cash
Purification and properties of ...
Rattus norvegicus
Biochimie
59
257-268
1977
-
-
-
-
-
-
19
2
-
-
2
-
-
1
-
-
1
1
-
1
1
-
2
1
-
-
-
-
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
19
-
2
-
-
2
-
-
-
-
1
-
1
1
-
2
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
288042
Tokunaga
Separation and properties of t ...
Euglena gracilis
Biochim. Biophys. Acta
429
55-62
1976
1
-
-
-
-
-
8
2
-
1
1
-
-
1
-
-
-
-
-
-
1
1
3
-
1
-
1
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
8
-
2
-
1
1
-
-
-
-
-
-
-
1
1
3
-
1
-
1
-
1
-
-
-
1
-
-
1
-
-
288167
Callewaert
Succinic semialdehyde dehydrog ...
Pseudomonas sp.
J. Biol. Chem.
248
6009-6013
1973
2
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
1
-
3
-
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-
-
-
1
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
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-
-
1
-
-
1
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
288168
Rosemblatt
Succinic semialdehyde dehydrog ...
Pseudomonas sp.
J. Biol. Chem.
248
6014-6018
1973
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
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-
-
-
-
-
-
1
1
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-
-
-
-
-
-
1
-
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-
1
-
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2
-
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-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288170
Albers
Succinic semialdehyde dehydrog ...
Platyrrhini
Biochim. Biophys. Acta
52
29-35
1961
1
-
-
-
-
2
6
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
1
-
1
1
-
3
-
-
-
1
-
-
3
-
-
2
-
6
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
1
-
1
1
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-