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Literature summary for 1.2.1.23 extracted from
- Purification of alpha-ketoaldehyde dehydrogenase from the human liver and its possible significance in the control of glycation (1989), Experientia, 45, 463-466.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| p-chloromercuribenzoate | - |
Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.24 | - |
methylglyoxal | - |
Homo sapiens | |
| 0.47 | - |
3-deoxygluconosone | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-deoxygluconosone + NAD+ + H2O | Homo sapiens | - |
3-deoxygluconic acid + NADH + H+ | - |
? | |
| methylglyoxal + NAD+ + H2O | Homo sapiens | - |
pyruvate + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| using acetone powder preparation, ammonium sulfate, column chromatography on DEAE-cellulose, affinity column packed with TSK-Gel AF-Red Toyopearl 650 ML and fast protein liquid chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 4.65 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoaldehydes + NAD+ + H2O | - |
Homo sapiens | 2-oxo acids + NADH | - |
? | |
| 3-deoxygluconosone + NAD+ + H2O | - |
Homo sapiens | 3-deoxygluconic acid + NADH + H+ | - |
? | |
| aldehydes + NAD+ + H2O | - |
Homo sapiens | carboxylic acids + NADH | - |
? | |
| methylglyoxal + NAD+ + H2O | - |
Homo sapiens | pyruvate + NADH + H+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 43000, SDS-PAGE | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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