Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.22 extracted from

  • Wolf, J.; Stark, H.; Fafenrot, K.; Albersmeier, A.; Pham, T.K.; Mueller, K.B.; Meyer, B.H.; Hoffmann, L.; Shen, L.; Albaum, S.P.; Kouril, T.; Schmidt-Hohagen, K.; Neumann-Schaal, M.; Braesen, C.; Kalinowski, J.; Wright, P.C.; Albers, S.V.; Schomburg, D.; Siebers, B.
    A systems biology approach reveals major metabolic changes in the thermoacidophilic archaeon Sulfolobus solfataricus in response to the carbon source L-fucose versus D-glucose (2016), Mol. Microbiol., 102, 882-908 .
    View publication on PubMed
Search for more literature for 1.2.1.22

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactaldehyde + NAD+ + H2O Saccharolobus solfataricus
-
 (S)-lactate + NADH + 2 H+
-
 ?
(S)-lactaldehyde + NAD+ + H2O Saccharolobus solfataricus P2
-
 (S)-lactate + NADH + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q97UA1 2,5-dioxopentanoate dehydrogenase, cf. EC 1.2.1.26
-
Saccharolobus solfataricus P2 Q97UA1 2,5-dioxopentanoate dehydrogenase, cf. EC 1.2.1.26
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactaldehyde + NAD+ + H2O
-
 Saccharolobus solfataricus (S)-lactate + NADH + 2 H+
-
 ?
(S)-lactaldehyde + NAD+ + H2O
-
 Saccharolobus solfataricus P2 (S)-lactate + NADH + 2 H+
-
 ?
(S)-lactaldehyde + NADP+ + H2O assay using NADP+ Saccharolobus solfataricus (S)-lactate + NADPH + 2 H+
-
 ?
(S)-lactaldehyde + NADP+ + H2O assay using NADP+ Saccharolobus solfataricus P2 (S)-lactate + NADPH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
L-lactaldehyde dehydrogenase
-
 Saccharolobus solfataricus
SSO3117 locus name Saccharolobus solfataricus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Saccharolobus solfataricus

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the last step in the degradation of L-fucose Saccharolobus solfataricus
physiological function the enzyme catalyzes the last step in the degradation of L-fucose. The activity with L-lactaldehyde is fivefold increased in L-fucose adapted cells compared with D-glucose. Only poor conversion of D-lactaldehyde under both conditions is observed Saccharolobus solfataricus