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Literature summary for 1.2.1.22 extracted from

  • Baldoma, L.; Aguilar, J.
    Involvement of lactaldehyde dehydrogenase in several metabolic pathways of Escherichia coli K12 (1987), J. Biol. Chem., 262, 13991-13996.
    View publication on PubMed
Search for more literature for 1.2.1.22

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ 50% inhibition at 5 mM Escherichia coli
Cu2+ 50% inhibition at 0.25 mM Escherichia coli
glyceraldehyde substrate inhibition Escherichia coli
glycolaldehyde substrate inhibition Escherichia coli
lactaldehyde substrate inhibition Escherichia coli
methylglyoxal substrate inhibition Escherichia coli
Mn2+ 50% inhibition at 10 mM Escherichia coli
p-hydroxymercuribenzoate 50% inhibition at 1.5 mM Escherichia coli
Zn2+ 50% inhibition at 0.4 mM Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
 L-lactaldehyde
-
 Escherichia coli
0.12
-
 NAD+ + L-lactaldehyde Escherichia coli
0.15
-
 L-glyceraldehyde
-
 Escherichia coli
0.28
-
 NAD+ cosubstrate glycolaldehyde Escherichia coli
0.38
-
 glycolaldehyde
-
 Escherichia coli
1
-
 methylglyoxal
-
 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 4 * 55000, SDS-PAGE Escherichia coli
220000
-
 gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactaldehyde + NAD+ Escherichia coli general role in aldehyde oxidation, involved in several metabolic pathways (S)-lactate + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 inducible under aerobic conditions
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactaldehyde + NAD+ general role in aldehyde oxidation, involved in several metabolic pathways Escherichia coli (S)-lactate + NADH
-
 ?
(S)-lactaldehyde + NAD+ + H2O
-
 Escherichia coli (S)-lactate + NADH + H+
-
 ir
glycolaldehyde + NAD+ + H2O
-
 Escherichia coli glycolate + NADH
-
 ir
L-glyceraldehyde + NAD+ + H2O
-
 Escherichia coli L-glycerate + NADH
-
 ir
methylglyoxal + NAD+ + H2O
-
 Escherichia coli pyruvate + NADH
-
 ir
additional information oxidizes several aldehydes, e.g. L-glyceraldehyde, glycolaldehyde, methylglyoxal Escherichia coli ?
-
 ?
additional information not: acetaldehyde, formaldehyde, propionaldehyde, succinic semialdehyde Escherichia coli ?
-
 ?

Subunits

Subunits Comment Organism
tetramer 4 * 55000, SDS-PAGE Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD+ four NAD-binding sites per molecule of native enzyme Escherichia coli