Cloned (Comment) | Organism |
---|---|
gene davD, recombinant expression in Escherichia coli strain W3110, coexpression with Pseudomonas putida gene gabT, encoding 5-aminovalerate aminotransferase, and davA and davB genes encoding delta-aminovaleramidase and lysine 2-monooxygenase, respectively. The recombinant Escherichia coli WL3110 strain expressingthe davAB and gabTD genes is cultured in a medium containing D-glucose, L-lysine, and 2-oxoglutarate, and produces glutarate | Pseudomonas putida |
Protein Variants | Comment | Organism |
---|---|---|
additional information | metabolic engineering strategies for the production of 5-aminovalerate from L-lysine in vivo synthesized from glucose in Escherichia coli by amplifying metabolic fluxes and activities, e.g. enzyme glutarate semialdehyde dehydrogenase, and by removing repressions and feedback inhibitions involved in L-lysine metabolism, oevrview | Pseudomonas putida |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutarate semialdehyde + NAD+ + H2O | Pseudomonas putida | - |
glutarate + NADH + 2 H+ | - |
? | |
glutarate semialdehyde + NAD+ + H2O | Pseudomonas putida ATCC 47054 | - |
glutarate + NADH + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas putida | Q88RC0 | - |
- |
Pseudomonas putida ATCC 47054 | Q88RC0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutarate semialdehyde + NAD+ + H2O | - |
Pseudomonas putida | glutarate + NADH + 2 H+ | - |
? | |
glutarate semialdehyde + NAD+ + H2O | - |
Pseudomonas putida ATCC 47054 | glutarate + NADH + 2 H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
davD | - |
Pseudomonas putida |
glutarate semialdehyde dehydrogenase | - |
Pseudomonas putida |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Pseudomonas putida |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in the metabolic pathways for the production of 5-aminovalerate and glutarate from L-lysine | Pseudomonas putida |