BRENDA - Enzyme Database
show all sequences of 1.2.1.16

Separation and properties of the NAD-linked and NADP-linked isozymes of succinic semialdehyde dehydrogenase in Euglena gracilis z

Tokunaga, M.; Nakano, Y.; Kitaoka, S.; Biochim. Biophys. Acta 429, 55-62 (1976)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
sulfhydryl reagents
beta-mercaptoethanol and dithiotreitol activate
Euglena gracilis
General Stability
General Stability
Organism
ethyleneglycol, 30%, stabilizes
Euglena gracilis
glycerol, 30%, stabilizes
Euglena gracilis
Inhibitors
Inhibitors
Commentary
Organism
Structure
5,5'-dithiobis(2-nitrobenzoate)
-
Euglena gracilis
glyoxylate
-
Euglena gracilis
N-ethylmaleimide
-
Euglena gracilis
p-chloromercuribenzoate
-
Euglena gracilis
potassium phosphate buffer
-
Euglena gracilis
Zn2+
-
Euglena gracilis
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.038
-
NADP+
-
Euglena gracilis
1.06
-
succinate semialdehyde
-
Euglena gracilis
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
K+
slight activation
Euglena gracilis
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
150000
-
gel filtration
Euglena gracilis
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Euglena gracilis
-
-
-
Purification (Commentary)
Commentary
Organism
ammonium sulfate fractionation and DEAE-cellulose
Euglena gracilis
Source Tissue
Source Tissue
Commentary
Organism
Textmining
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
7.94
-
-
Euglena gracilis
Storage Stability
Storage Stability
Organism
5°C, complete inactivation after 2 days
Euglena gracilis
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
malonic semialdehyde + NADP+ + H2O
hydrolyzed at 8.7% the rate of succinate semialdehyde
288042
Euglena gracilis
malonate + NADPH + H+
-
288042
Euglena gracilis
?
succinate semialdehyde + NADP+ + H2O
-
288042
Euglena gracilis
succinate + NADPH + H+
-
288042
Euglena gracilis
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
35
45
-
Euglena gracilis
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
60
-
up to, in presence of 30% glycerol
Euglena gracilis
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.7
-
-
Euglena gracilis
pH Range
pH Minimum
pH Maximum
Commentary
Organism
7.5
9.5
-
Euglena gracilis
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
specific for
Euglena gracilis
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
sulfhydryl reagents
beta-mercaptoethanol and dithiotreitol activate
Euglena gracilis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
specific for
Euglena gracilis
General Stability (protein specific)
General Stability
Organism
ethyleneglycol, 30%, stabilizes
Euglena gracilis
glycerol, 30%, stabilizes
Euglena gracilis
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
5,5'-dithiobis(2-nitrobenzoate)
-
Euglena gracilis
glyoxylate
-
Euglena gracilis
N-ethylmaleimide
-
Euglena gracilis
p-chloromercuribenzoate
-
Euglena gracilis
potassium phosphate buffer
-
Euglena gracilis
Zn2+
-
Euglena gracilis
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.038
-
NADP+
-
Euglena gracilis
1.06
-
succinate semialdehyde
-
Euglena gracilis
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
K+
slight activation
Euglena gracilis
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
150000
-
gel filtration
Euglena gracilis
Purification (Commentary) (protein specific)
Commentary
Organism
ammonium sulfate fractionation and DEAE-cellulose
Euglena gracilis
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
7.94
-
-
Euglena gracilis
Storage Stability (protein specific)
Storage Stability
Organism
5°C, complete inactivation after 2 days
Euglena gracilis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
malonic semialdehyde + NADP+ + H2O
hydrolyzed at 8.7% the rate of succinate semialdehyde
288042
Euglena gracilis
malonate + NADPH + H+
-
288042
Euglena gracilis
?
succinate semialdehyde + NADP+ + H2O
-
288042
Euglena gracilis
succinate + NADPH + H+
-
288042
Euglena gracilis
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
35
45
-
Euglena gracilis
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
60
-
up to, in presence of 30% glycerol
Euglena gracilis
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.7
-
-
Euglena gracilis
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
7.5
9.5
-
Euglena gracilis
Other publictions for EC 1.2.1.16
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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1
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-
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1
4
-
-
-
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
4
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
4
4
743077
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-
1
-
-
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1
5
-
-
-
4
-
89
-
-
1
-
-
-
-
-
4
1
-
-
-
4
-
-
-
3
2
-
-
-
-
1
3
-
-
-
-
1
2
5
-
-
-
4
-
-
-
1
-
-
-
-
4
1
-
-
-
4
-
-
-
-
-
1
1
-
4
4
743290
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37
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-
-
1
1
-
-
-
3
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
1
1
-
-
2
1
-
-
2
-
-
-
-
-
1
2
1
-
-
-
-
-
3
-
-
-
1
-
-
-
1
-
-
-
-
2
1
1
-
-
2
1
-
-
-
-
1
1
-
2
2
722211
Esser
Unraveling the function of par ...
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17
205-216
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-
-
2
-
-
-
-
9
-
-
3
5
-
5
-
-
2
-
-
-
-
-
10
2
-
-
-
9
-
-
-
4
-
-
-
-
-
2
4
-
-
-
-
-
-
9
-
-
3
5
-
-
-
2
-
-
-
-
10
2
-
-
-
9
-
-
-
-
-
-
-
-
10
10
724602
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Archaeal aldehyde dehydrogenas ...
Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7
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1344-1348
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-
-
1
-
3
-
1
4
-
-
2
-
-
5
-
-
-
-
-
-
-
-
6
1
1
-
-
4
1
-
-
2
-
-
-
-
-
1
2
-
3
-
-
1
-
4
-
-
2
-
-
-
-
-
-
-
-
-
6
1
1
-
-
4
1
-
-
-
-
-
-
-
4
4
726463
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1
-
1
1
11
-
1
18
-
-
2
12
-
4
-
-
1
-
-
-
-
-
12
1
-
-
-
18
1
-
-
2
-
-
-
1
-
1
2
1
11
-
-
1
-
18
-
-
2
12
-
-
-
1
-
-
-
-
12
1
-
-
-
18
1
-
-
-
-
-
-
-
17
17
741378
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Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720
Proteins Struct. Funct. Bioinform.
81
1031-1041
2013
-
-
-
1
11
-
1
18
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
18
-
-
-
2
-
-
-
-
-
-
2
1
11
-
-
1
-
18
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
18
-
-
-
-
-
-
-
-
18
18
723864
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Crystallization and preliminar ...
Streptococcus pyogenes
Acta Crystallogr. Sect. F
68
288-291
2012
-
-
1
1
-
-
-
-
-
-
1
2
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
1
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724115
de Carvalho
On the chemical mechanism of s ...
Mycobacterium tuberculosis
Arch. Biochem. Biophys.
509
90-99
2011
-
-
-
-
-
-
2
4
-
6
-
3
-
3
1
-
1
-
-
-
-
-
3
-
-
-
-
4
-
1
-
2
1
-
-
-
-
-
2
-
-
-
-
2
1
4
-
6
-
3
-
1
-
1
-
-
-
-
3
-
-
-
-
4
-
1
-
-
-
-
-
-
4
4
698627
Mayer
Homotaurine metabolized to 3-s ...
Cupriavidus necator
J. Bacteriol.
191
6052-6058
2009
1
-
-
-
-
1
-
3
-
-
1
2
-
4
-
-
1
-
-
1
1
-
2
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
3
-
-
1
2
-
-
-
1
-
1
1
-
2
1
-
-
-
-
-
1
1
-
1
1
1
1
-
-
685387
Yeung
Physical, kinetic and spectrop ...
Pseudomonas putida
Biochim. Biophys. Acta
1784
1248-1255
2008
1
-
1
-
5
1
-
8
-
-
3
2
-
2
-
-
1
-
-
-
1
1
21
1
1
-
-
6
1
2
1
2
-
-
-
1
-
1
2
-
5
1
-
-
-
8
-
-
3
2
-
-
-
1
-
-
1
1
21
1
1
-
-
6
1
2
1
-
-
-
-
-
-
-
690736
Jaeger
Saturation transfer difference ...
Drosophila melanogaster
Biochem. Biophys. Res. Commun.
372
400-406
2008
-
-
1
-
1
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
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-
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2
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1
2
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1
-
-
1
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678422
Saehuan
Isolation and characterization ...
Pseudomonas stutzeri, Pseudomonas stutzeri ST-201
Biochim. Biophys. Acta
1770
1585-1592
2007
-
-
1
-
-
-
-
4
-
-
-
2
-
2
-
-
1
-
-
-
-
-
4
-
-
-
-
4
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
4
-
-
-
2
-
-
-
1
-
-
-
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
692836
Fuhrer
Computational prediction and e ...
Escherichia coli, Escherichia coli BW25113
J. Bacteriol.
189
8073-8078
2007
1
1
1
-
1
-
-
-
-
-
-
-
-
29
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
1
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288054
Lutke-Eversloh
Biochemical and molecular char ...
Cupriavidus necator
FEMS Microbiol. Lett.
181
63-71
1999
-
-
1
-
-
-
-
-
-
-
-
1
-
6
-
-
-
-
-
-
11
-
2
-
1
-
1
-
1
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
11
-
2
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
288053
Vissers
Induction of the 4-aminobutyra ...
Saccharomyces cerevisiae
Eur. J. Biochem.
187
611-616
1990
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
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-
-
-
-
-
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-
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-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288038
Sanchez
Purification and properties of ...
Klebsiella pneumoniae
Biochim. Biophys. Acta
990
225-231
1989
1
-
-
-
-
-
1
5
-
1
3
1
-
3
-
-
1
-
-
-
10
-
4
1
-
-
-
-
1
-
-
2
-
-
-
1
-
-
2
-
-
-
-
1
-
5
-
1
3
1
-
-
-
1
-
-
10
-
4
1
-
-
-
-
1
-
-
-
1
-
-
1
-
-
288052
Vissers
Positive and negative regulato ...
Saccharomyces cerevisiae
Eur. J. Biochem.
181
357-361
1989
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707583
Sanchez
Properties and functions of tw ...
Pseudomonas putida
Biochim. Biophys. Acta
953
249-257
1988
2
-
-
-
-
-
2
2
-
-
2
-
-
1
-
-
-
1
-
-
1
-
2
1
-
-
-
-
-
-
-
2
-
-
-
2
-
-
2
-
-
-
-
2
-
2
-
-
2
-
-
-
-
-
-
-
1
-
2
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
288037
Ramos
Mutations affecting the enzyme ...
Saccharomyces cerevisiae
Eur. J. Biochem.
149
401-404
1985
2
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1
2
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1
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2
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1
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7
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2
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1
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2
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2
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2
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1
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2
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1
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1
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7
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2
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1
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288039
Donelly
Succinic semialdehyde dehydrog ...
Escherichia coli
Eur. J. Biochem.
113
555-561
1981
1
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-
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1
2
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1
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11
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3
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1
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1
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1
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1
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1
2
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11
-
3
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1
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288051
Metzer
-
Isolation and properties of Es ...
Escherichia coli
J. Bacteriol.
137
111-1118
1979
-
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1
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1
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8
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2
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1
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1
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1
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8
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2
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288040
Blakley
The catabolism of L-tyrosine b ...
Arthrobacter sp.
Can. J. Microbiol.
23
1128-1139
1977
-
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-
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2
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1
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1
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4
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2
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2
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2
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1
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4
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288042
Tokunaga
Separation and properties of t ...
Euglena gracilis
Biochim. Biophys. Acta
429
55-62
1976
1
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-
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2
6
2
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1
1
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3
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1
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1
1
1
2
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1
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1
-
1
1
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1
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1
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1
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2
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6
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2
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1
1
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1
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1
1
1
2
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1
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1
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1
1
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-
-
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-
288049
Maitre
In vitro studies into the effe ...
Rattus norvegicus, Rattus norvegicus Wistar
FEBS Lett.
72(1)
53-57
1976
-
-
-
-
-
-
-
-
-
-
-
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167
-
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-
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2
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2
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2
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2
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288050
Walsh
Studies on the control of 4-am ...
Rattus norvegicus, Rattus norvegicus Wistar
Biochem. J.
160
147-157
1976
-
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-
-
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4
2
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167
-
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1
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1
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2
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1
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1
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4
2
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1
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1
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2
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288043
Dover
Novel type of catabolite repre ...
Escherichia coli
FEBS Lett.
37
207-211
1973
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1
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1
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2
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1
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2
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288048
Sims
Subcellular distribution of su ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Eur. J. Biochem.
35
450-453
1973
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3
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2
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2
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163
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2
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4
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2
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3
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2
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2
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2
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4
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2
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288044
Yambe
Succinate semialdehyde dehydro ...
Rhodobacter sphaeroides
J. Biochem.
70
243-247
1971
1
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3
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2
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1
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1
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1
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2
2
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2
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1
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2
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3
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1
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1
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1
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2
2
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288045
Padmanabhan
Nicotinamide adenine dinucleot ...
Pseudomonas sp.
J. Bacteriol.
100
398-402
1969
-
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1
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10
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1
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10
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1
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288041
Jakoby
-
Enzymes of gamma-aminobutyrate ...
Pseudomonas fluorescens
Methods Enzymol.
5
765-778
1962
-
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-
-
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3
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1
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1
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1
1
2
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1
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2
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2
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3
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1
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1
1
2
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1
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1
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287170
Nirenberg
Enzymatic utilization of gamma ...
Pseudomonas sp.
J. Biol. Chem.
235
954-960
1960
-
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-
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1
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1
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1
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1
1
1
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1
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2
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2
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1
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1
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1
1
1
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1
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288046
Jakoby
Aldehyde oxidation III. Succin ...
Pseudomonas fluorescens
J. Biol. Chem.
234
937-940
1959
3
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-
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3
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1
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1
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1
1
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1
1
1
2
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3
-
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2
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3
-
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1
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1
1
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1
1
1
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