BRENDA - Enzyme Database show
show all sequences of 1.2.1.16

The catabolism of L-tyrosine by an Arthrobacter sp.

Blakley, E.R.; Can. J. Microbiol. 23, 1128-1139 (1977)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
succinate semialdehyde + NADP+ + H2O
Arthrobacter sp.
degradation of 3,4-dihydroxyphenylacetate in Arthrobacter sp.
succinate + NADPH + H+
-
Arthrobacter sp.
?
succinate semialdehyde + NADP+ + H2O
Arthrobacter sp. PRL W15
degradation of 3,4-dihydroxyphenylacetate in Arthrobacter sp.
succinate + NADPH + H+
-
Arthrobacter sp. PRL W15
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arthrobacter sp.
-
-
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
-
Arthrobacter sp.
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
succinate semialdehyde + NADP+ + H2O
-
288040
Arthrobacter sp.
succinate + NADPH + H+
-
288040
Arthrobacter sp.
?
succinate semialdehyde + NADP+ + H2O
degradation of 3,4-dihydroxyphenylacetate in Arthrobacter sp.
288040
Arthrobacter sp.
succinate + NADPH + H+
-
288040
Arthrobacter sp.
?
succinate semialdehyde + NADP+ + H2O
-
288040
Arthrobacter sp. PRL W15
succinate + NADPH + H+
-
288040
Arthrobacter sp. PRL W15
?
succinate semialdehyde + NADP+ + H2O
degradation of 3,4-dihydroxyphenylacetate in Arthrobacter sp.
288040
Arthrobacter sp. PRL W15
succinate + NADPH + H+
-
288040
Arthrobacter sp. PRL W15
?
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
rate with NADP+ is about twice that with NAD+, crude extract
Arthrobacter sp.
NADP+
rate with NADP+ is about twice that with NAD+, crude extract
Arthrobacter sp.
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
rate with NADP+ is about twice that with NAD+, crude extract
Arthrobacter sp.
NADP+
rate with NADP+ is about twice that with NAD+, crude extract
Arthrobacter sp.
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
succinate semialdehyde + NADP+ + H2O
Arthrobacter sp.
degradation of 3,4-dihydroxyphenylacetate in Arthrobacter sp.
succinate + NADPH + H+
-
Arthrobacter sp.
?
succinate semialdehyde + NADP+ + H2O
Arthrobacter sp. PRL W15
degradation of 3,4-dihydroxyphenylacetate in Arthrobacter sp.
succinate + NADPH + H+
-
Arthrobacter sp. PRL W15
?
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
-
Arthrobacter sp.
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
succinate semialdehyde + NADP+ + H2O
-
288040
Arthrobacter sp.
succinate + NADPH + H+
-
288040
Arthrobacter sp.
?
succinate semialdehyde + NADP+ + H2O
degradation of 3,4-dihydroxyphenylacetate in Arthrobacter sp.
288040
Arthrobacter sp.
succinate + NADPH + H+
-
288040
Arthrobacter sp.
?
succinate semialdehyde + NADP+ + H2O
-
288040
Arthrobacter sp. PRL W15
succinate + NADPH + H+
-
288040
Arthrobacter sp. PRL W15
?
succinate semialdehyde + NADP+ + H2O
degradation of 3,4-dihydroxyphenylacetate in Arthrobacter sp.
288040
Arthrobacter sp. PRL W15
succinate + NADPH + H+
-
288040
Arthrobacter sp. PRL W15
?
Other publictions for EC 1.2.1.16
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740855
Park
Kinetic characterization and m ...
Bacillus subtilis 168, Bacillus subtilis
J. Microbiol. Biotechnol.
24
954-958
2014
-
-
1
-
-
-
1
4
-
-
-
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
4
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
4
4
743077
Park
Kinetic characterization and ...
Bacillus subtilis 168, Bacillus subtilis
J. Microbiol. Biotechnol.
24
954-958
2014
-
-
1
-
-
-
1
5
-
-
-
4
-
89
-
-
1
-
-
-
-
-
4
1
-
-
-
4
-
-
-
3
2
-
-
-
-
1
3
-
-
-
-
1
2
5
-
-
-
4
-
-
-
1
-
-
-
-
4
1
-
-
-
4
-
-
-
-
-
1
1
-
4
4
743290
Jang
Kinetic and structural charac ...
Streptococcus pyogenes
Mol. Cells
37
719-726
2014
-
-
1
1
-
-
-
3
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
1
1
-
-
2
1
-
-
2
-
-
-
-
-
1
2
1
-
-
-
-
-
3
-
-
-
1
-
-
-
1
-
-
-
-
2
1
1
-
-
2
1
-
-
-
-
1
1
-
2
2
722211
Esser
Unraveling the function of par ...
Escherichia coli, Saccharolobus solfataricus
Extremophiles
17
205-216
2013
-
-
2
-
-
-
-
9
-
-
3
5
-
5
-
-
2
-
-
-
-
-
10
2
-
-
-
9
-
-
-
4
-
-
-
-
-
2
4
-
-
-
-
-
-
9
-
-
3
5
-
-
-
2
-
-
-
-
10
2
-
-
-
9
-
-
-
-
-
-
-
-
10
10
724602
Ito
Archaeal aldehyde dehydrogenas ...
Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7
Biosci. Biotechnol. Biochem.
77
1344-1348
2013
-
-
1
-
3
-
1
4
-
-
2
-
-
5
-
-
-
-
-
-
-
-
6
1
1
-
-
4
1
-
-
2
-
-
-
-
-
1
2
-
3
-
-
1
-
4
-
-
2
-
-
-
-
-
-
-
-
-
6
1
1
-
-
4
1
-
-
-
-
-
-
-
4
4
726463
Zheng
Structure and activity of the ...
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium LT2
Proteins
81
1031-1041
2013
1
-
1
1
11
-
1
18
-
-
2
12
-
4
-
-
1
-
-
-
-
-
12
1
-
-
-
18
1
-
-
2
-
-
-
1
-
1
2
1
11
-
-
1
-
18
-
-
2
12
-
-
-
1
-
-
-
-
12
1
-
-
-
18
1
-
-
-
-
-
-
-
17
17
741378
Zheng
Structure and activity of the ...
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720
Proteins Struct. Funct. Bioinform.
81
1031-1041
2013
-
-
-
1
11
-
1
18
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
18
-
-
-
2
-
-
-
-
-
-
2
1
11
-
-
1
-
18
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
18
-
-
-
-
-
-
-
-
18
18
723864
Jang
Crystallization and preliminar ...
Streptococcus pyogenes
Acta Crystallogr. Sect. F
68
288-291
2012
-
-
1
1
-
-
-
-
-
-
1
2
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
1
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724115
de Carvalho
On the chemical mechanism of s ...
Mycobacterium tuberculosis
Arch. Biochem. Biophys.
509
90-99
2011
-
-
-
-
-
-
2
4
-
6
-
3
-
3
1
-
1
-
-
-
-
-
3
-
-
-
-
4
-
1
-
2
1
-
-
-
-
-
2
-
-
-
-
2
1
4
-
6
-
3
-
1
-
1
-
-
-
-
3
-
-
-
-
4
-
1
-
-
-
-
-
-
4
4
698627
Mayer
Homotaurine metabolized to 3-s ...
Cupriavidus necator
J. Bacteriol.
191
6052-6058
2009
1
-
-
-
-
1
-
3
-
-
1
2
-
4
-
-
1
-
-
1
1
-
2
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
3
-
-
1
2
-
-
-
1
-
1
1
-
2
1
-
-
-
-
-
1
1
-
1
1
1
1
-
-
685387
Yeung
Physical, kinetic and spectrop ...
Pseudomonas putida
Biochim. Biophys. Acta
1784
1248-1255
2008
1
-
1
-
5
1
-
8
-
-
3
2
-
2
-
-
1
-
-
-
1
1
21
1
1
-
-
6
1
2
1
2
-
-
-
1
-
1
2
-
5
1
-
-
-
8
-
-
3
2
-
-
-
1
-
-
1
1
21
1
1
-
-
6
1
2
1
-
-
-
-
-
-
-
690736
Jaeger
Saturation transfer difference ...
Drosophila melanogaster
Biochem. Biophys. Res. Commun.
372
400-406
2008
-
-
1
-
1
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678422
Saehuan
Isolation and characterization ...
Pseudomonas stutzeri, Pseudomonas stutzeri ST-201
Biochim. Biophys. Acta
1770
1585-1592
2007
-
-
1
-
-
-
-
4
-
-
-
2
-
2
-
-
1
-
-
-
-
-
4
-
-
-
-
4
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
4
-
-
-
2
-
-
-
1
-
-
-
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
692836
Fuhrer
Computational prediction and e ...
Escherichia coli, Escherichia coli BW25113
J. Bacteriol.
189
8073-8078
2007
1
1
1
-
1
-
-
-
-
-
-
-
-
29
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
1
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288054
Lutke-Eversloh
Biochemical and molecular char ...
Cupriavidus necator
FEMS Microbiol. Lett.
181
63-71
1999
-
-
1
-
-
-
-
-
-
-
-
1
-
6
-
-
-
-
-
-
11
-
2
-
1
-
1
-
1
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
11
-
2
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
288053
Vissers
Induction of the 4-aminobutyra ...
Saccharomyces cerevisiae
Eur. J. Biochem.
187
611-616
1990
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288038
Sanchez
Purification and properties of ...
Klebsiella pneumoniae
Biochim. Biophys. Acta
990
225-231
1989
1
-
-
-
-
-
1
5
-
1
3
1
-
3
-
-
1
-
-
-
10
-
4
1
-
-
-
-
1
-
-
2
-
-
-
1
-
-
2
-
-
-
-
1
-
5
-
1
3
1
-
-
-
1
-
-
10
-
4
1
-
-
-
-
1
-
-
-
1
-
-
1
-
-
288052
Vissers
Positive and negative regulato ...
Saccharomyces cerevisiae
Eur. J. Biochem.
181
357-361
1989
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707583
Sanchez
Properties and functions of tw ...
Pseudomonas putida
Biochim. Biophys. Acta
953
249-257
1988
2
-
-
-
-
-
2
2
-
-
2
-
-
1
-
-
-
1
-
-
1
-
2
1
-
-
-
-
-
-
-
2
-
-
-
2
-
-
2
-
-
-
-
2
-
2
-
-
2
-
-
-
-
-
-
-
1
-
2
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
288037
Ramos
Mutations affecting the enzyme ...
Saccharomyces cerevisiae
Eur. J. Biochem.
149
401-404
1985
2
-
-
-
-
-
1
2
-
-
-
1
-
2
-
-
1
-
-
-
7
-
2
-
-
-
-
-
1
-
-
2
-
-
-
2
-
-
2
-
-
-
-
1
-
2
-
-
-
1
-
-
-
1
-
-
7
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
288039
Donelly
Succinic semialdehyde dehydrog ...
Escherichia coli
Eur. J. Biochem.
113
555-561
1981
1
-
-
-
-
-
-
-
-
-
1
2
-
1
-
-
-
-
-
-
11
-
3
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
11
-
3
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
288051
Metzer
-
Isolation and properties of Es ...
Escherichia coli
J. Bacteriol.
137
111-1118
1979
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
8
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
8
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288040
Blakley
The catabolism of L-tyrosine b ...
Arthrobacter sp.
Can. J. Microbiol.
23
1128-1139
1977
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288042
Tokunaga
Separation and properties of t ...
Euglena gracilis
Biochim. Biophys. Acta
429
55-62
1976
1
-
-
-
-
2
6
2
-
1
1
-
-
3
-
-
1
-
-
1
1
1
2
-
1
-
1
-
1
1
-
1
-
-
-
1
-
-
1
-
-
2
-
6
-
2
-
1
1
-
-
-
-
1
-
1
1
1
2
-
1
-
1
-
1
1
-
-
-
-
-
-
-
-
288049
Maitre
In vitro studies into the effe ...
Rattus norvegicus, Rattus norvegicus Wistar
FEBS Lett.
72(1)
53-57
1976
-
-
-
-
-
-
-
-
-
-
-
-
-
167
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288050
Walsh
Studies on the control of 4-am ...
Rattus norvegicus, Rattus norvegicus Wistar
Biochem. J.
160
147-157
1976
-
-
-
-
-
-
-
4
2
-
-
-
-
167
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
4
2
-
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288043
Dover
Novel type of catabolite repre ...
Escherichia coli
FEBS Lett.
37
207-211
1973
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288048
Sims
Subcellular distribution of su ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Eur. J. Biochem.
35
450-453
1973
-
-
-
-
-
-
3
-
2
-
-
2
-
163
-
-
-
-
-
2
-
-
4
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
2
-
-
-
-
-
2
-
-
4
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
288044
Yambe
Succinate semialdehyde dehydro ...
Rhodobacter sphaeroides
J. Biochem.
70
243-247
1971
1
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
1
-
-
-
1
-
1
-
-
-
-
-
2
2
-
2
-
-
-
1
-
-
2
-
-
-
-
-
-
3
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
288045
Padmanabhan
Nicotinamide adenine dinucleot ...
Pseudomonas sp.
J. Bacteriol.
100
398-402
1969
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
10
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288041
Jakoby
-
Enzymes of gamma-aminobutyrate ...
Pseudomonas fluorescens
Methods Enzymol.
5
765-778
1962
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
1
-
-
-
1
1
2
-
-
-
-
-
1
-
1
2
-
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
1
1
2
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
287170
Nirenberg
Enzymatic utilization of gamma ...
Pseudomonas sp.
J. Biol. Chem.
235
954-960
1960
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
1
1
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
288046
Jakoby
Aldehyde oxidation III. Succin ...
Pseudomonas fluorescens
J. Biol. Chem.
234
937-940
1959
3
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
1
-
-
-
-
-
1
1
1
2
-
-
-
3
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
-
1
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-