Literature summary for 1.2.1.13 extracted from

Min, J.; Kyung Kim, Y.; Cipriani, P.G.; Kang, M.; Khersonsky, S.M.; Walsh, D.P.; Lee, J.Y.; Niessen, S.; Yates, J.R.; Gunsalus, K.; Piano, F.; Chang, Y.T.
Forward chemical genetic approach identifies new role for GAPDH in insulin signaling (2007), Nat. Chem. Biol., 3, 55-59.

Search for more literature for 1.2.1.13

Application

Application	Comment	Organism
medicine	the results suggest that GAPDH is an active regulator in the phosphoinositide-mediated signaling pathway and a potential new target for insulin resistance treatment, diabetes, obesity and aging research	Oryctolagus cuniculus
medicine	the results suggest that GAPDH is an active regulator in the phosphoinositide-mediated signaling pathway and a potential new target for insulin resistance treatment, diabetes, obesity and aging research	Caenorhabditis elegans

Inhibitors

Inhibitors	Comment	Organism	Structure
6-Hydroxydopamine	-	Oryctolagus cuniculus
GAPDH segregator	GAPDS stimulates insulin signaling by segregating the tetrameric GAPDH into monomers, and thereby suppresses the intrinsic GAPDH activation of phosphoinositide's phosphatase activity	Caenorhabditis elegans
GAPDH segregator	GAPDH segregator, GAPDS, stimulates insulin signaling by segregating the tetrameric GAPDH into monomers, and thereby suppresses the intrinsic GAPDH activation of phosphoinositide's phosphatase activity	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	-	-	-
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
muscle	-	Oryctolagus cuniculus	-

Subunits

Subunits	Comment	Organism
homotetramer	-	Oryctolagus cuniculus
tetramer	-	Caenorhabditis elegans

Synonyms

Synonyms	Comment	Organism
GAPDH	-	Oryctolagus cuniculus
GAPDH	-	Caenorhabditis elegans
glyceraldehyde-3-phosphate dehydrogenase	-	Oryctolagus cuniculus
glyceraldehyde-3-phosphate dehydrogenase	-	Caenorhabditis elegans

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.008	-	-	Oryctolagus cuniculus	6-Hydroxydopamine
0.015	-	GAPDS inhibits the glycolytic enzymatic function of GAPDH	Oryctolagus cuniculus	GAPDH segregator

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)