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Literature summary for 1.2.1.13 extracted from

  • Verho, R.; Richard, P.; Jonson, P.H.; Sundqvist, L.; Londesborough, J.; Penttila, M.
    Identification of the first fungal NADP-GAPDH from Kluyveromyces lactis (2002), Biochemistry, 41, 13833-13838.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Kluyveromyces lactis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
NADP+ pH 9.2, 30°C Kluyveromyces lactis
0.5
-
NAD+ pH 9.2, 30°C Kluyveromyces lactis
0.75
-
D-glyceraldehyde 3-phosphate pH 9.2, 30°C, reaction with NAD+ or NADP+ Kluyveromyces lactis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
x * 40000, SDS-PAGE Kluyveromyces lactis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Kluyveromyces lactis the transcription of the gene is upregulated during growth on D-xylose, which suggests that the enzyme is involved in regeneration of NADPH needed for xylose assimilation ?
-
?

Organism

Organism UniProt Comment Textmining
Kluyveromyces lactis Q8J0C9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
Kluyveromyces lactis 3-phospho-D-glyceroyl phosphate + NADH
-
?
D-glyceraldehyde 3-phosphate + phosphate + NADP+
-
Kluyveromyces lactis 3-phospho-D-glyceroyl phosphate + NADPH
-
?
additional information the transcription of the gene is upregulated during growth on D-xylose, which suggests that the enzyme is involved in regeneration of NADPH needed for xylose assimilation Kluyveromyces lactis ?
-
?

Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE Kluyveromyces lactis

Synonyms

Synonyms Comment Organism
NADP-GAPDH
-
Kluyveromyces lactis
phosphorylating glyceraldehyde-3-phosphate dehydrogenase
-
Kluyveromyces lactis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Kluyveromyces lactis
NADP+
-
Kluyveromyces lactis