Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | highest activation at 1 mM | Homo sapiens | |
dithioerythritol | highest activation at 1 mM | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-chloromercuribenzoate | complete inhibition at 10 mM | Homo sapiens | |
4-hydroxymercuribenzoate | complete inhibition at 10 mM | Homo sapiens | |
5'-AMP | - |
Homo sapiens | |
ADP | - |
Homo sapiens | |
cAMP | about 80% inhibition at 30 mM, competitive versus NAD+ | Homo sapiens | |
Cu2+ | complete inhibition at 10 mM | Homo sapiens | |
D-glyceraldehyde 3-phosphate | 2-mercaptoethanol protects against the inhibition | Homo sapiens | |
Hg2+ | complete inhibition at 10 mM | Homo sapiens | |
NADH | 2-mercaptoethanol protects against the inhibition, but the inhibitory effect of NADH is not influenced by heavy metal ions or EDTA | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glyceraldehyde 3-phosphate + phosphate + NAD+ | Homo sapiens | - |
3-phospho-D-glyceroyl phosphate + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04406 | - |
- |
Purification (Comment) | Organism |
---|---|
from HeLa cells | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glyceraldehyde 3-phosphate + phosphate + NAD+ | - |
Homo sapiens | 3-phospho-D-glyceroyl phosphate + NADH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
D-glyceraldehyde-3-phosphate dehydrogenase | - |
Homo sapiens |
GAPDH | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NADH | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.6 | - |
cAMP | pH and temperature not specified in the publication | Homo sapiens | |
1 | - |
5'-AMP | pH and temperature not specified in the publication | Homo sapiens | |
2.1 | - |
ADP | pH and temperature not specified in the publication | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in glycolysis, the glycolytic conversion of glucose to pyruvic acid | Homo sapiens |
physiological function | the enzyme is involved in glycolysis, the pathway plays an important role in tumor cells | Homo sapiens |