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Literature summary for 1.2.1.12 extracted from
- Possible role of NAD-dependent glyceraldehyde-3-phosphate dehydrogenase in growth promotion of Arabidopsis seedlings by low levels of selenium (2015), Biosci. Biotechnol. Biochem., 79, 1579-1586 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Arabidopsis thaliana | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glyceraldehyde 3-phosphate + phosphate + NAD+ | Arabidopsis thaliana | - |
3-phospho-D-glyceroyl phosphate + NADH + H+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme 142-175fold by ultracentrifugation, ammonium sulfate fractionation, hydrophobic interaction chromatography, ultrafiltration, and gel filtration | Arabidopsis thaliana |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seedling | - |
Arabidopsis thaliana | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glyceraldehyde 3-phosphate + phosphate + NAD+ | - |
Arabidopsis thaliana | 3-phospho-D-glyceroyl phosphate + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NAD-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
Arabidopsis thaliana |
| NAD-GAPDH | - |
Arabidopsis thaliana |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 28 | - |
assay at | Arabidopsis thaliana |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Arabidopsis thaliana |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Arabidopsis thaliana | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Arabidopsis thaliana | respiration, ATP levels, and the activity of NAD-dependent glyceraldehyde-3-phosphate dehydrogenase are enhanced in Arabidopsis thaliana grown in medium containing 0.1 mM selenium. Addition of an inhibitor of glutathione (GSH) synthesis to the medium abolishes both the Se-dependent growth promotion and enzyme NAD-GAPDH upregulation. Selenate-dependent variation in NAD-GAPDH levels | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | possible role of NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase in growth promotion of Arabidopsis seedlings by low levels of selenium. The pro-growth effect of selenium arises enhancing mitochondrial performance in a GSH-dependent manner, in which NAD-GAPDH may serve as a key regulator | Arabidopsis thaliana |
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