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Literature summary for 1.2.1.12 extracted from

  • Zhou, Y.; Yi, X.; Stoffer, J.B.; Bonafe, N.; Gilmore-Hebert, M.; McAlpine, J.; Chambers, S.K.
    The multifunctional protein glyceraldehyde-3-phosphate dehydrogenase is both regulated and controls colony-stimulating factor-1 messenger RNA stability in ovarian cancer (2008), Mol. Cancer Res., 6, 1375-1384.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine among 256 ovarian and fallopian tube cancer specimens, GAPDH is regulated, with almost 50% of specimens having no GAPDH staining.Low GAPDH staining is associated with a low macrophage colony stimulating factor CSF-1 score Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
NOSE1 cell normal human ovarian surface epithelial cell line Homo sapiens
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ovarian carcinoma cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function downregulation of GAPDH using siRNA reduces both macrophage colony stimulating factor CSF-1 mRNA and protein levels, through destabilizing CSF-1 mRNA. CSF-1 mRNA half-lives are decreased by 50% in the presence of GAPDH siRNA. GAPDH associates with a large AU-rich containing regionof CSF-1 Homo sapiens