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Literature summary for 1.2.1.12 extracted from

  • Jarczowski, F.; Jahreis, G.; Erdmann, F.; Schierhorn, A.; Fischer, G.; Edlich, F.
    FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor (2009), J. Biol. Chem., 284, 766-773.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 cell Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
FK506-binding protein 36 i.e. FKBP36. The interaction between FKBP36 and GAPDH directly inhibits the catalytic activity of GAPDH. FKBP36 expression causes a significant reduction of the GAPDH level and activity in COS-7 cells. GAPDH is depleted by FKBP36 expression, particularly in the cytosolic fraction Homo sapiens
FK506-binding protein 36 i.e. FKBP36, forms complexes with glyceraldehyde-3-phosphate dehydrogenase and Hsp90. Both proteins bind independently to different sites of the FKBP36 tetratricopeptide repeat domain. The interaction between FKBP36 and GAPDH directly inhibits the catalytic activity of GAPDH Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Oryctolagus cuniculus
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
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Oryctolagus cuniculus
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muscle
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Oryctolagus cuniculus
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