Literature summary for 1.2.1.12 extracted from

Harada, N.; Yasunaga, R.; Higashimura, Y.; Yamaji, R.; Fujimoto, K.; Moss, J.; Inui, H.; Nakano, Y.
Glyceraldehyde-3-phosphate dehydrogenase enhances transcriptional activity of androgen receptor in prostate cancer cells (2007), J. Biol. Chem., 282, 22651-22661.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	GAPDH functions as a coactivator with high selectivity for androgen receptor and enhances androgen receptor transactivation independent of its glycolytic activity	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in prostate cancer cell lines PC-3 and LNCaP	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	protein complex containing GAPDH and androgen receptor in the cytosol	Homo sapiens	5829	-
nucleus	protein complex containing GAPDH and androgen receptor in the nucleus	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P04406	-	-

Purification (Commentary)

Purification (Comment)	Organism
analytical centrifugation	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+	-	Homo sapiens	3-phospho-D-glyceroyl phosphate + NADH + H+	-	r

Synonyms

Synonyms	Comment	Organism
GAPDH	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)