Literature summary for 1.2.1.12 extracted from

Graven, K.K.; Bellur, D.; Klahn, B.D.; Lowrey, S.L.; Amberger, E.
HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells (2003), Biochim. Biophys. Acta, 1626, 10-18.

Search for more literature for 1.2.1.12

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	hypoxia upregulates the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase in endothelial cells through a 5'-hypoxic regulatory element. Cell-specific patterns of HIF-1alpha and HIF-2alpha expression lead to cell-specific gene upregulation during hypoxia	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	lung, microvascular	Homo sapiens	-
lung	microvascular endothelial cell	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	hypoxia upregulates the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase in endothelial cells through a 5'-hypoxic regulatory element. Cell-specific patterns of HIF-1alpha and HIF-2alpha expression lead to cell-specific gene upregulation during hypoxia	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
GAPDH	-	Homo sapiens
glyceraldehyde-3-phosphate dehydrogenase	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)