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Literature summary for 1.2.1.12 extracted from

  • Wang, C.S.; Alaupovic, P.
    Glyceraldehyde-3-phosphate dehydrogenase from human erythrocyte membranes. Kinetic mechanism and competitive substrate inhibition by glyceraldehyde 3-phosphate (1980), Arch. Biochem. Biophys., 205, 136-145.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,3-diphosphoglycerate
-
Homo sapiens
ATP noncompetitive inhibitor Homo sapiens
D-glyceraldehyde 3-phosphate substrate inhibition Homo sapiens
NADH
-
Homo sapiens
NO3- uncompetitive inhibitor with NAD+, dead end inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane isolated from human erytrocyt ghosts Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+ Homo sapiens glycolytic enzyme 3-phospho-D-glyceroyl phosphate + NADH
-
?
additional information Homo sapiens enzyme is regulated by ATP and by D-glyceraldehyde 3-phosphate ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+ ordered ter bi mechanism characterized by the sequential addition of NAD+, glyceraldehyde 3-phosphate and phosphate to the enzyme and the sequential release of 3-phospho-D-glyceroyl phosphate and NADH from the enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
98
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
Homo sapiens 3-phospho-D-glyceroyl phosphate + NADH
-
?
D-glyceraldehyde 3-phosphate + phosphate + NAD+ glycolytic enzyme Homo sapiens 3-phospho-D-glyceroyl phosphate + NADH
-
?
additional information enzyme is regulated by ATP and by D-glyceraldehyde 3-phosphate Homo sapiens ?
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens