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Literature summary for 1.2.1.11 extracted from

  • Khan, S.; Somvanshi, P.; Bhardwaj, T.; Mandal, R.K.; Dar, S.A.; Wahid, M.; Jawed, A.; Lohani, M.; Khan, M.; Areeshi, M.Y.; Haque, S.
    Aspartate-beta-semialdeyhyde dehydrogenase as a potential therapeutic target of Mycobacterium tuberculosis H37Rv Evidence from in silico elementary mode analysis of biological network model (2018), J. Cell. Biochem., 119, 2832-2842 .
    View publication on PubMed
Search for more literature for 1.2.1.11

Cloned(Commentary)

Cloned (Comment) Organism
gene asd, phylogenetic analysis Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
curcumin
-
 Mycobacterium tuberculosis
huperzine A
-
 Mycobacterium tuberculosis
additional information molecular docking and simulation studies of the priority target, enzyme ASD, reveals the therapeutic potential of the ASD inhibitors based on selected natural products (huperzine A, rosmarinic acid, and curcumin), overview Mycobacterium tuberculosis
rosmarinic acid
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate 4-semialdehyde + phosphate + NADP+ Mycobacterium tuberculosis
-
 L-4-aspartyl phosphate + NADPH + H+
-
 r
L-aspartate 4-semialdehyde + phosphate + NADP+ Mycobacterium tuberculosis H37Rv
-
 L-4-aspartyl phosphate + NADPH + H+
-
 r
L-aspartate 4-semialdehyde + phosphate + NADP+ Mycobacterium tuberculosis ATCC 25618
-
 L-4-aspartyl phosphate + NADPH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WNX5
-
-
Mycobacterium tuberculosis ATCC 25618 P9WNX5
-
-
Mycobacterium tuberculosis H37Rv P9WNX5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Mycobacterium tuberculosis L-4-aspartyl phosphate + NADPH + H+
-
 r
L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Mycobacterium tuberculosis H37Rv L-4-aspartyl phosphate + NADPH + H+
-
 r
L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Mycobacterium tuberculosis ATCC 25618 L-4-aspartyl phosphate + NADPH + H+
-
 r

Synonyms

Synonyms Comment Organism
ASADH
-
 Mycobacterium tuberculosis
Asd
-
 Mycobacterium tuberculosis
aspartate-beta-semialdeyhyde dehydrogenase
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Mycobacterium tuberculosis
NADPH
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
metabolism mathematical modeling of the lysine metabolism in Mycobacterium tuberculosis strain H37Rv involving the enzyme, overview Mycobacterium tuberculosis