Cloned (Comment) | Organism |
---|---|
expression Escherichia coli | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-2-amino-5-fluoro-4-oxo-5-phosphono-pentanoic acid | irreversible inhibition | Escherichia coli | |
(S)-2-amino-5-phosphono-pent-4-ynoic acid | - |
Escherichia coli | |
acetylenic and z-olefinic analogues | competitive inhibition | Bacteria |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate 4-semialdehyde + phosphate + NADP+ | Bacteria | - |
L-4-aspartyl phosphate + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacteria | - |
- |
- |
Escherichia coli | P0A9Q9 | - |
- |
Purification (Comment) | Organism |
---|---|
to homogeneity | Escherichia coli |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Escherichia coli | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-4-aspartyl phosphate + NADPH | - |
Escherichia coli | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
? | |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
Bacteria | L-4-aspartyl phosphate + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ASA-DH | - |
Bacteria |
ASA-DH | - |
Escherichia coli |
aspartate semialdehyde dehydrogenase | - |
Escherichia coli |
aspartate-semialdehyde dehydrogenase | - |
Bacteria |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Bacteria | |
NADPH | - |
Bacteria | |
NADPH | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.2 | - |
(S)-2-amino-5-fluoro-4-oxo-5-phosphono-pentanoic acid | 0.2 M Tris, 1 mM EDTA, pH 8.6, 15 mM phosphate, 0.15 mM NADP+, 37°C | Escherichia coli | |
3.9 | - |
(S)-2-amino-5-phosphono-pent-4-ynoic acid | 0.2 M Tris, 1 mM EDTA, pH 8.6, 15 mM phosphate, 0.15 mM NADP+, 37°C | Escherichia coli | |
20 | - |
z-olefin | - |
Bacteria |