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Literature summary for 1.2.1.11 extracted from

  • Cox, R.J.; Gibson, J.S.; Hadfield, A.T.
    Design, synthesis and analysis of inhibitors of bacterial aspartate semialdehyde dehydrogenase (2005), ChemBiochem, 6, 2255-2260.
    View publication on PubMed
Search for more literature for 1.2.1.11

Cloned(Commentary)

Cloned (Comment) Organism
expression Escherichia coli Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
(S)-2-amino-5-fluoro-4-oxo-5-phosphono-pentanoic acid irreversible inhibition Escherichia coli
(S)-2-amino-5-phosphono-pent-4-ynoic acid
-
 Escherichia coli
acetylenic and z-olefinic analogues competitive inhibition Bacteria

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate 4-semialdehyde + phosphate + NADP+ Bacteria
-
 L-4-aspartyl phosphate + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Bacteria
-
-
-
Escherichia coli P0A9Q9
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity Escherichia coli

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-4-aspartyl phosphate + NADPH
-
 Escherichia coli L-aspartate 4-semialdehyde + phosphate + NADP+
-
 ?
L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Bacteria L-4-aspartyl phosphate + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
ASA-DH
-
 Bacteria
ASA-DH
-
 Escherichia coli
aspartate semialdehyde dehydrogenase
-
 Escherichia coli
aspartate-semialdehyde dehydrogenase
-
 Bacteria

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Bacteria
NADPH
-
 Bacteria
NADPH
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2
-
 (S)-2-amino-5-fluoro-4-oxo-5-phosphono-pentanoic acid 0.2 M Tris, 1 mM EDTA, pH 8.6, 15 mM phosphate, 0.15 mM NADP+, 37°C Escherichia coli
3.9
-
 (S)-2-amino-5-phosphono-pent-4-ynoic acid 0.2 M Tris, 1 mM EDTA, pH 8.6, 15 mM phosphate, 0.15 mM NADP+, 37°C Escherichia coli
20
-
 z-olefin
-
 Bacteria