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Literature summary for 1.2.1.11 extracted from
- Oxyanion specificity of L-Aspartate-beta-semialdehyde dehydrogenase (1999), Inorg. Chem., 38, 818-820.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Periodate | - |
Escherichia coli |  |
| perrhenate | very weak inhibitor | Escherichia coli | |
| phosphonate | weak inhibitor | Escherichia coli | |
| tellurate | - |
Escherichia coli | |
| tungstate | - |
Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.14 | - |
vanadate | - |
Escherichia coli | |
| 1.6 | - |
arsenate | - |
Escherichia coli | |
| 2.9 | - |
phosphate | - |
Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-4-aspartyl phosphate + NADPH | Escherichia coli | - |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-4-aspartyl phosphate + NADPH | - |
Escherichia coli | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
? | |
| L-aspartate 4-semialdehyde + arsenate + NADP+ | - |
Escherichia coli | ? | - |
r | |
| L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
Escherichia coli | L-4-aspartyl phosphate + NADPH | - |
r | |
| L-aspartate 4-semialdehyde + vanadate + NADP+ | - |
Escherichia coli | ? | - |
r | |
| additional information | the putative phosphate side contains arginine and a lysine that can provide electrostratic attraction to bind an oxyanion | Escherichia coli | ? | - |
? | |
| additional information | the kinetic parameters with arsenate are comparable to those of phosphate, vanadate is an excellent substrate for the enzyme | Escherichia coli | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Escherichia coli | |
| NADPH | - |
Escherichia coli | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.22 | - |
Periodate | - |
Escherichia coli | |
| 11 | - |
tellurate | - |
Escherichia coli | |
| 17 | - |
phosphonate | - |
Escherichia coli | |
| 26 | - |
tungstate | - |
Escherichia coli | |
| 140 | - |
perrhenate | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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