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Literature summary for 1.2.1.105 extracted from

  • Araujo, W.L.; Trofimova, L.; Mkrtchyan, G.; Steinhauser, D.; Krall, L.; Graf, A.; Fernie, A.R.; Bunik, V.I.
    On the role of the mitochondrial 2-oxoglutarate dehydrogenase complex in amino acid metabolism (2013), Amino Acids, 44, 683-700 .
    View publication on PubMed
Search for more literature for 1.2.1.105

Inhibitors

Inhibitors Comment Organism Structure
succinyl phosphonate synthetic analog of 2-oxoglutarate Arabidopsis thaliana
succinyl phosphonate synthetic analog of 2-oxoglutarate Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-
mitochondrion
-
 Arabidopsis thaliana 5739
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Rattus norvegicus
-
seedling
-
 Arabidopsis thaliana
-

Synonyms

Synonyms Comment Organism
OGDHC
-
 Rattus norvegicus
OGDHC
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function organisms possessing OGDHC respond to succinyl phosphonate inhibition by significantly changing their amino acid pools. Increases in Glu, 4-aminobutanoate and alanine represent the most universal change, and strong perturbation in the relative abundance of amino acids due to the OGDHC inhibition is accompanied by decreased protein content Rattus norvegicus
physiological function organisms possessing OGDHC respond to succinyl phosphonate inhibition by significantly changing their amino acid pools. Increases in Glu, 4-aminobutanoate and alanine represent the most universal change, and strong perturbation in the relative abundance of amino acids due to the OGDHC inhibition is accompanied by decreased protein content Arabidopsis thaliana