Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
inner membrane | - |
Trypanosoma brucei | - |
- |
mitochondrial matrix | - |
Trypanosoma brucei | 5759 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
alpha-KDE2 | - |
Trypanosoma brucei |
dihydrolipoyl succinyltransferase E2 | part of the multisubunit alpha-ketoglutarate dehydrogenase complex | Trypanosoma brucei |
General Information | Comment | Organism |
---|---|---|
malfunction | RNAi knockdown-inducted bloodstream trypanosomes show pronounced growth reduction and often fail to equally distribute kinetoplast DNA to daughter cells, resulting in accumulation of cells devoid of kinetoplast DNA or containing two kinetoplasts | Trypanosoma brucei |
physiological function | the enzyme is bifunctional, both as a metabolic enzyme and as a mitochondrial inheritance factor necessary for the distribution of kinetoplast DNA networks to daughter cells at cytokinesis | Trypanosoma brucei |