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Literature summary for 1.2.1.105 extracted from

  • Sykes, S.E.; Hajduk, S.L.
    Dual functions of alpha-ketoglutarate dehydrogenase E2 in the Krebs cycle and mitochondrial DNA inheritance in Trypanosoma brucei (2013), Eukaryot. Cell, 12, 78-90.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
inner membrane
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Trypanosoma brucei
-
-
mitochondrial matrix
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Trypanosoma brucei 5759
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Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Synonyms

Synonyms Comment Organism
alpha-KDE2
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Trypanosoma brucei
dihydrolipoyl succinyltransferase E2 part of the multisubunit alpha-ketoglutarate dehydrogenase complex Trypanosoma brucei

General Information

General Information Comment Organism
malfunction RNAi knockdown-inducted bloodstream trypanosomes show pronounced growth reduction and often fail to equally distribute kinetoplast DNA to daughter cells, resulting in accumulation of cells devoid of kinetoplast DNA or containing two kinetoplasts Trypanosoma brucei
physiological function the enzyme is bifunctional, both as a metabolic enzyme and as a mitochondrial inheritance factor necessary for the distribution of kinetoplast DNA networks to daughter cells at cytokinesis Trypanosoma brucei