Literature summary for 1.2.1.105 extracted from

Santos, S.S.; Gibson, G.E.; Cooper, A.J.; Denton, T.T.; Thompson, C.M.; Bunik, V.I.; Alves, P.M.; Sonnewald, U.
Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons (2006), J. Neurosci. Res., 83, 450-458.

Search for more literature for 1.2.1.105

Application

Application	Comment	Organism
medicine	potential of succinyl phosphonate esters for modeling the biochemical and pathophysiological consequences of reduced KGDHC activity in brain diseases	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
4-oxo-4-phosphonobutanoic acid	affects (1-13C)glucose and (U-13C)glutamate metabolism, phosphonoethyl and carboxy ethyl ester reduce the concentration of aspartate, alanine and gamma-aminobutyric acid, phosphonoethyl ester reduces gluthatione content, carboxy ethyl ester reduces the intracellular concentration of valine and leucine	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
cerebellum	-	Mus musculus	-
neuron	cerebellar granule neurons	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	KGDHC is an important component of the tricarboxylic acid cycle	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
alpha-ketoglutarate dehydrogenase	-	Mus musculus
alpha-ketoglutarate dehydrogenase complex	-	Mus musculus
E1k	-	Mus musculus
KGDHC	-	Mus musculus

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Release 2023.1 (January 2023)