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Literature summary for 1.2.1.105 extracted from

  • Strumilo, S.
    Short-term regulation of the alpha-ketoglutarate dehydrogenase complex by energy-linked and some other effectors (2005), Biochemistry, 70, 726-729.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ADP
-
Escherichia coli
ADP
-
Homo sapiens
ADP
-
Rattus norvegicus
ADP
-
Sus scrofa
ADP
-
Bos taurus
ADP
-
Solanum tuberosum
ADP
-
Columba livia
inorganic phosphate
-
Solanum tuberosum
phosphate
-
Escherichia coli
phosphate
-
Sus scrofa
phosphate
-
Bison bison
thiamine diphosphate KGDHC is saturated with endogenous tightly bound thiamine diphosphate, but the addition of exogenous thiamine diphosphate to the reaction medium leads to a marked increase in KGDHC affinity to 2-oxoglutarate Bison bison

Inhibitors

Inhibitors Comment Organism Structure
ATP inhibits KGDHC in the kidney, in adrenals the effect is rather weak Bos taurus
ATP weakly inhibits in breast muscles Columba livia
ATP inhibits KGDHC in the heart Sus scrofa
NADH allosteric inhibition Bos taurus
NADH allosteric inhibition Columba livia

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Rattus norvegicus
Ca2+
-
Sus scrofa
Ca2+
-
Bos taurus
Mn2+
-
Bison bison
additional information Ca2+ is no activator Escherichia coli
additional information Ca2+ is no activator Solanum tuberosum

Organism

Organism UniProt Comment Textmining
Bison bison
-
-
-
Bos taurus
-
-
-
Columba livia
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Solanum tuberosum
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
Columba livia
-
heart
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
heart
-
Sus scrofa
-
heart
-
Bison bison
-
kidney
-
Bos taurus
-
additional information adrenals Bos taurus
-
muscle
-
Columba livia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Sus scrofa [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Columba livia [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
?
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Bison bison [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
?

Synonyms

Synonyms Comment Organism
alpha-ketoglutarate dehydrogenase complex
-
Escherichia coli
alpha-ketoglutarate dehydrogenase complex
-
Homo sapiens
alpha-ketoglutarate dehydrogenase complex
-
Rattus norvegicus
alpha-ketoglutarate dehydrogenase complex
-
Sus scrofa
alpha-ketoglutarate dehydrogenase complex
-
Bos taurus
alpha-ketoglutarate dehydrogenase complex
-
Solanum tuberosum
alpha-ketoglutarate dehydrogenase complex
-
Columba livia
alpha-ketoglutarate dehydrogenase complex
-
Bison bison
KGDHC
-
Escherichia coli
KGDHC
-
Homo sapiens
KGDHC
-
Rattus norvegicus
KGDHC
-
Sus scrofa
KGDHC
-
Bos taurus
KGDHC
-
Solanum tuberosum
KGDHC
-
Columba livia
KGDHC
-
Bison bison