Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Escherichia coli | |
ADP | - |
Homo sapiens | |
ADP | - |
Rattus norvegicus | |
ADP | - |
Sus scrofa | |
ADP | - |
Bos taurus | |
ADP | - |
Solanum tuberosum | |
ADP | - |
Columba livia | |
inorganic phosphate | - |
Solanum tuberosum | |
phosphate | - |
Escherichia coli | |
phosphate | - |
Sus scrofa | |
phosphate | - |
Bison bison | |
thiamine diphosphate | KGDHC is saturated with endogenous tightly bound thiamine diphosphate, but the addition of exogenous thiamine diphosphate to the reaction medium leads to a marked increase in KGDHC affinity to 2-oxoglutarate | Bison bison |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP | inhibits KGDHC in the kidney, in adrenals the effect is rather weak | Bos taurus | |
ATP | weakly inhibits in breast muscles | Columba livia | |
ATP | inhibits KGDHC in the heart | Sus scrofa | |
NADH | allosteric inhibition | Bos taurus | |
NADH | allosteric inhibition | Columba livia |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Rattus norvegicus | |
Ca2+ | - |
Sus scrofa | |
Ca2+ | - |
Bos taurus | |
Mn2+ | - |
Bison bison | |
additional information | Ca2+ is no activator | Escherichia coli | |
additional information | Ca2+ is no activator | Solanum tuberosum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bison bison | - |
- |
- |
Bos taurus | - |
- |
- |
Columba livia | - |
- |
- |
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Solanum tuberosum | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | - |
Columba livia | - |
heart | - |
Homo sapiens | - |
heart | - |
Rattus norvegicus | - |
heart | - |
Sus scrofa | - |
heart | - |
Bison bison | - |
kidney | - |
Bos taurus | - |
additional information | adrenals | Bos taurus | - |
muscle | - |
Columba livia | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Sus scrofa | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
? | |
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Columba livia | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
? | |
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Bison bison | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-ketoglutarate dehydrogenase complex | - |
Escherichia coli |
alpha-ketoglutarate dehydrogenase complex | - |
Homo sapiens |
alpha-ketoglutarate dehydrogenase complex | - |
Rattus norvegicus |
alpha-ketoglutarate dehydrogenase complex | - |
Sus scrofa |
alpha-ketoglutarate dehydrogenase complex | - |
Bos taurus |
alpha-ketoglutarate dehydrogenase complex | - |
Solanum tuberosum |
alpha-ketoglutarate dehydrogenase complex | - |
Columba livia |
alpha-ketoglutarate dehydrogenase complex | - |
Bison bison |
KGDHC | - |
Escherichia coli |
KGDHC | - |
Homo sapiens |
KGDHC | - |
Rattus norvegicus |
KGDHC | - |
Sus scrofa |
KGDHC | - |
Bos taurus |
KGDHC | - |
Solanum tuberosum |
KGDHC | - |
Columba livia |
KGDHC | - |
Bison bison |