Literature summary for 1.2.1.105 extracted from

Zhang, L.; Cooper, A.J.; Krasnikov, B.F.; Xu, H.; Bubber, P.; Pinto, J.T.; Gibson, G.E.; Hanigan, M.H.
Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells (2006), Biochemistry, 45, 8959-8971.

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Application

Application	Comment	Organism
medicine	susceptibility of KGDHC to inactivation in kidney cells exposed to cisplatin metabolites my be due to the proximity of mitochondrial aspartate aminotransferase to KGDHC in mitochondria, mitochondrial aspartate aminotransferase may catalyze a beta-lyase reaction with the cisplatin-cysteine S-conjugate, converting cisplatin to a toxicant	Sus scrofa

Inhibitors

Inhibitors	Comment	Organism	Structure
cisplatin	treatment with 0.05 or 0.1 mM for 3 h, followed by removal of cisplatin from the medium for 24 h, results in a pronounced loss of activity, both in mitochondrial aspartate aminotransferase-transfected cells and control cells, exposure to 0.1 mM results in a significantly greater loss of activity in mitochondrial aspartate aminotransferase-transfected cells than in control cells	Sus scrofa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Sus scrofa	5739	-

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Sus scrofa	-
LLC-PK1 cell	-	Sus scrofa	-

Synonyms

Synonyms	Comment	Organism
alpha-ketoglutarate dehydrogenase complex	-	Sus scrofa
KGDHC	-	Sus scrofa

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Release 2023.1 (January 2023)