Literature summary for 1.2.1.105 extracted from

Tanaka, N.; Koike, K.; Hamada, M.; Otsuka, K.; Suematsu, T.; Koike, M.
Mammalian alpha-keto acid dehydrogenase complexes. VII. Resolution and reconstitution of the pig heart 2-oxoglutarate dehydrogenase complex (1972), J. Biol. Chem., 247, 4043-4049.

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Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
2-oxoglutarate dehydrogenase complex	Sus scrofa

Reaction

Reaction	Comment	Organism	Reaction ID
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2	the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH	Sus scrofa	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-oxoglutarate + lipoamide	-	Sus scrofa	S-succinyldihydrolipoamide + CO2	-	?

Subunits

Subunits	Comment	Organism
More	biochemical and microsopic data indicate that the complex is a mosaic comprising 1 molecule of lipoate succinyltransferase, 6 molecules of 2-oxoglutarate dehydrogenase and 6 molecules of lipoamide dehydrogenase	Sus scrofa

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Release 2023.1 (January 2023)