Literature summary for 1.2.1.104 extracted from

Moeller, J.; Bhat, K.; Guhl, L.; Poertner, R.; Jandt, U.; Zeng, A.P.
Regulation of pyruvate dehydrogenase complex related to lactate switch in CHO cells (2021), Eng. Life Sci., 21, 100-114 .

Search for more literature for 1.2.1.104

Organism

Organism	UniProt	Comment	Textmining
Cricetulus griseus	G3H5K6	E1 component subunit alpha, cf. EC 1.2.4.1	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	during lactate consumption, component E1 subunuit alpha Ser293 and Ser300 phosphorylation levels are 33% higher compared to the phase of glucose excess. At the same time, the relative phosphorylation level of Ser232 increases steadily throughout the cultivation (66% increase overall)	Cricetulus griseus

Synonyms

Synonyms	Comment	Organism
PDH	-	Cricetulus griseus

General Information

General Information	Comment	Organism
physiological function	during lactate consumption, component E1 subunit alpha Ser293 and Ser300 phosphorylation levels are 33% higher compared to the phase of glucose excess. At the same time, the relative phosphorylation level of Ser232 increases steadily throughout the cultivation (66% increase overall). The intracellular pyruvate accumulates only during the period of high lactate production, while acetyl-CoA shows nearly no accumulation	Cricetulus griseus

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Release 2023.1 (January 2023)