Literature summary for 1.2.1.104 extracted from

Liu, Y.J.; Fan, X.Y.; Zhang, D.D.; Xia, Y.Z.; Hu, Y.J.; Jiang, F.L.; Zhou, F.L.; Liu, Y.
Dual inhibition of pyruvate dehydrogenase complex and respiratory chain complex induces apoptosis by a mitochondria-targeted fluorescent organic arsenical in vitro and in vivo (2020), ChemMedChem, 15, 552-558 .

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Application

Application	Comment	Organism
medicine	the acute promyelocytic leukemia is greatly alleviated in the PDT-PAO-F16 treated group in an acute promyelocytic leukemia mice model	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
1-[3-[4-(1,3,2-dithiarsinan-2-yl)anilino]-3-oxopropyl]-4-[(E)-2-(1H-indol-3-yl)ethenyl]pyridin-1-ium	i.e. PDT-PAO-16, organic arsenal inhibitor, mainly accumulates in mitochondria within hours and suppresses the activity of the pyruvate dehydrogenase complex resulting in the inhibition of ATP synthesis and thermogenesis disorder. The suppression of respiratory chain complex I and IV accelerates the mitochondrial dysfunction leading to caspase family-dependent apoptosis. In vivo, the acute promyelocytic leukemia is greatly alleviated in the PDT-PAO-F16 treated group in an acute promyelocytic leukemia mice model	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P08559 and P11177 and O00330 and P10515 and P09622	P08559 i.e. subunit PdhA1, cf. EC 1.2.4.1, P11177 i.e. subunit PdhB1, cf. EC 1.2.4.1, O00330 i.e. subunit PdhX, P10515 i.e. subunit DlaT, cf. EC 2.3.1.12, P09622 i.e. subunit Dld, cf. EC 1.8.1.4, respectively	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
NB-4 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)