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Literature summary for 1.2.1.104 extracted from

  • Patel, M.S.; Korotchkina, L.G.; Sidhu, S.
    Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex (2009), J. Mol. Catal. B, 61, 2-6.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.104

Protein Variants

Protein Variants Comment Organism
D289A the mutant does not have any detectable activity in PDC assay while its activity in thedecarboxylation reaction measured by 2,6-dichlorophenolindophenol assay does not significantly change Homo sapiens
D289N the mutant does not demonstrate any change in the 2,6-dichlorophenolindophenol assay but its activity is reduced to 67% in PDC assay Homo sapiens
E229A the mutant does not show any significant changes compared with the wild type subunit E1 activity Homo sapiens
E229Q the mutant does not show any significant changes compared with the wild type subunit E1 activity Homo sapiens
E232A the mutant does not show any significant changes compared with the wild type subunit E1 activity Homo sapiens
E232Q the mutant does not show any significant changes compared with the wild type subunit E1 activity Homo sapiens
E234A the mutant does not show any significant changes compared with the wild type subunit E1 activity Homo sapiens
E234Q the mutant does not show any significant changes compared with the wild type subunit E1 activity Homo sapiens
I329A the mutant shows reductions in activities in both the 2,6-dichlorophenolindophenol and PDC assays Homo sapiens
I329del the mutant shows reductions in activities in both the 2,6-dichlorophenolindophenol and PDC assays Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the pyruvate dehydrogenase complex consists of multiple copies of several components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2), dihydrolipoamide dehydrogenase (E3), E3-binding protein (BP), and specific kinases and phosphatases ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the pyruvate dehydrogenase complex consists of multiple copies of several components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2), dihydrolipoamide dehydrogenase (E3), E3-binding protein (BP), and specific kinases and phosphatases Homo sapiens ?
-
 ?
pyruvate + CoA + NAD+
-
 Homo sapiens acetyl-CoA + CO2 + NADH
-
 ?
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol
-
 Homo sapiens acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
-
 ?

Synonyms

Synonyms Comment Organism
PDC
-
 Homo sapiens
PDH
-
 Homo sapiens
pyruvate dehydrogenase complex
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
thiamine diphosphate
-
 Homo sapiens